Cleaved-F2RL3 (G48) Antibody

1. Data suggested that PAR4-AP-induced platelet reactivity between PAR4 rs773902 was associated with altered intensity of Ca(2+) mobilization and ERK activation. PMID:29289806
2. Thrombin binding to extra-cellular loop II (ECLII) of PAR4 is important for its cleavage and activation of PAR4. PMID:28448853
3. PAR4 has a role in mediating platelet aggregation; its blockade provides antithrombotic activity PMID:28053157
4. PAR4 is required for platelet procoagulant function during thrombus formation in human blood PMID:26878340
5. Prospective study demonstrated that AHRR and F2RL3 methylation levels had inverse relationships with self-reported smoking status and accurately discriminated for both current- and former- smoking. Moreover, methylation markers distinguished former smokers from never-smokers with high accuracy and significantly associated with an increased risk of lung cancer. PMID:28453567
6. F2RL3 variants have the potential to markedly alter platelet PAR4 reactivity particularly after exposure to therapeutic PAR1 antagonists. PMID:26966273
7. these findings are the first to show that internalization of activated PAR4 is linked to proper ERK1/2 and Akt activation. PMID:27402844
8. an intracellular PAR4 C-terminal motif that regulates calcium signaling and beta-arrestin interactions, was identified. PMID:28126849
9. the contribution of PAR1 and PAR4 to thrombin-mediated activation of the platelet fibrin receptor (GPIIbIIIa), is reported. PMID:27784794
10. Suppression of PAR4 expression has no significant effect on the proliferation of SW620 cells, but can inhibit the migration of the cells. PMID:27126938
11. Both GPIbalpha and PAR4 are required for thrombin-induced reactive oxygen species formation in human platelets. PMID:26569550
12. Bladder PAR activation elicits urothelial MIF release and urothelial MIF receptor signaling at least partly through CXCR4 to result in abdominal hypersensitivity without overt bladder inflammation PMID:26020638
13. protease-activated receptor 4 and Trefoil factor 2 are expressed in human colorectal cancer PMID:25876034
14. The PAR4 expression and activation via intracellular signaling pathways and the role of PAR4 signaling pathways in the development and maintenance of pain. PMID:25664811
15. This review summarizes the roles of PAR4 in coagulation and other extracellular protease pathways. PMID:25120239
16. Findings suggested that F2RL3 methylation is a very strong predictor of lung cancer risk and mortality, particularly at older age. PMID:25821117
17. Lower F2RL3 methylation is a strong predictor of mortality, including all-cause, cardiovascular, cancer and other mortality. Systemic adverse effects of smoking may be mediated by pathways associated with F2RL3 methylation. PMID:24510982
18. exosite II is critical for activation of PAR4. PMID:24990072
19. provide evidence against the hypothesis that PAR-1 and PAR-4 stimulation of platelets trigger differential release of alpha-granules PMID:24776597
20. Washed platelets from black volunteers were hyperaggregable in response to PAR4-mediated platelet stimulation compared with whites. PMID:25278289
21. PAR-4 appears to play a hitherto unsuspected role in diabetic vasculopathy. PMID:25239438
22. Quantitative trait locus analysis identified 3 common single nucleotide polymorphisms in the PAR4 gene (F2RL3) associated with PAR4-induced platelet aggregation. Thr120 was more common in blacks than whites. PMID:25293779
23. PAR4-P2Y12 association supports arrestin-mediated sustained signaling to Akt. PMID:24723492
24. PAR4 and GPVI-mediated platelet reactivity involves 12-lipoxygenase PMID:23784669
25. Phosphatidylcholine transfer protein contributes to the racial difference in PAR4-mediated platelet activation. PMID:24216752
26. The F2RL3 rs773857 risk allele homozygotes are associated with risk for increased platelet count and hyperactivity. PMID:22228373
27. Stimulation of PAR4 on platelets leads to faster and more robust thrombin generation, compared to PAR-1 stimulation. PMID:23307185
28. The results seem to indicate methylation in F2RL3 to be a potential mediator of the detrimental impact of smoking and mortality in coronary heart disease PMID:22511653
29. PAR4 is down-regulated in the colonic mast cells of post-infectious irritable bowel syndrome. PMID:22151913
30. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4). PMID:22411985
31. mutations that disrupted dimer formation had reduced calcium mobilization in response to the PAR4 agonist peptide. PMID:22318735
32. PKC inhibition markedly enhances Ca2+ signaling and phosphatidylserine exposure downstream of protease-activated receptor-1 but not protease-activated receptor-4 in human platelets. PMID:21649850
33. down-regulation of PAR4 expression occurs frequently in gastric cancers and exhibits association with more aggressive gastric cancer PMID:21635966
34. The present study elucidates further differences in human platelet PAR signalling regulation and provides evidence for a cross-talk in which PAR4 signalling counteracts mechanisms involved in PAR1 signalling down-regulation. PMID:21391917
35. High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB. PMID:21164077
36. Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2alpha differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. PMID:21127289
37. Results suggest that lower levels of protease-activated receptors 1 and 4 contribute to the poor thrombin induced aggregation observed with newborn platelets, which can not be compensated by higher levels of GPIbalpha. PMID:20807173
38. Low concentrations of alpha-thrombin accelerate tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells, and this effect is mediated by PAR-3 and PAR-4. PMID:20930172
39. Human cytomegalovirus induces PARs expression through transcriptional activation in endothelial cells, increasing sensitivity to thrombin. PMID:20155436
40. SPSB1 and SPSB4 bind strongly to both Par-4 and VASA peptides. PMID:20561531
41. Data show that PAR1 and PAR4-activating peptides were as effective as thrombin in inducing annexin V binding in combination with collagen-related peptide in diluted whole blood and platelet rich plasma, but not in washed platelets. PMID:20230207
42. Thrombin enhances the migration of chondrosarcoma cells by increasing MMP-2 and MMP-13 expression through the PAR/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway. PMID:20175118
43. Complement protease MASP-1 activates human endothelial cells through PAR4 cleavage PMID:19667088
44. When expressed in respiratory epithelial cells and cell lines, protease-activated receptor 4 (PAR4)induces the release of IL-6, IL-8, and PGE2. PMID:11907122
45. Activation of platelets via the PAR4 pathway, by treatment with PAR4 agonist peptide AYPGKF, results in thrombin-induced thromboxane production by platelets. PMID:12006403
46. The signal from PAR4 stabilizes platelet-platelet aggregate formation in the absence of P2Y12 activation by ADP. PMID:12008957
47. PAR4 is activated independently of GPIbalpha and ADP PMID:12871418
48. Important role in regulation of thromboxane formation in platelets responding to thrombin through prolonged elevation of [Ca(2+)](i) and activation of phospholipase A(2). Can be activated by relatively low concentrations of thrombin in human platelets. PMID:12888878
49. Protease-activated receptor-4 exodomains utilize dual prolines and an anionic retention motif for thrombin recognition and cleavage. PMID:13678420
50. PAR-1 and PAR-4 have roles in activating GPIb translocation into the cytoskeleton in platelets PMID:14521606

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HGNC: 3540

UNIGENE: Hs.137574

KEGG: hsa:9002

STRING: 9606.ENSP00000248076

OMIM: 602779