GPRC5A Antibody

Code: CSB-PA009850GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,IHC

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Target Background

Product Details

Uniprot NO.

Q8NFJ5

Target Names

GPRC5A

Alternative Names

GPRC5A; GPCR5A; RAI3; RAIG1; Retinoic acid-induced protein 3; G-protein coupled receptor family C group 5 member A; Phorbol ester induced gene 1; PEIG-1; Retinoic acid-induced gene 1 protein; RAIG-1

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human GPRC5A,RAI3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor.

Gene References into Functions

GPRC5a was upregulated in pancreatic cancer (PaCa) leading to an enhanced drug resistance in PaCa cells. PMID:29949874
under-expressed GPRC5A during lung tumorigenesis enhances any transcriptional stimulation through an active translational status. PMID:27273304
findings reveal an unprecedented role for GPRC5A in regulation of the ITGB1-mediated cell adhesion and it's downstream signaling, thus indicating a potential novel role for GPRC5A in human epithelial cancers. PMID:27715394
miR-204 inhibits cell proliferation in gastric cancer by targeting CKS1B, CXCL1 and GPRC5A. PMID:29283424
p53 overexpression and GPRC5A induction markedly inhibited tumor cell viability and induced apoptosis. PMID:28849235
GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR. PMID:27415424
These results suggest RAI3 plays an important role in adipogenesis of hASCs and may have a potential use in the future application. PMID:28870805
Study underscores genomic alterations that represent early events in the development of Kras mutant LUAD following Gprc5a loss and tobacco carcinogen exposure. PMID:28653505
Suppression of GPRC5a results in decreased cell growth, proliferation and migration in pancreatic cancer cell lines via a STAT3 modulated pathway, independent from ERK activation PMID:28114355
our results implicate GPRC5A as a tumor suppressor in breast cancer cells, and GPRC5A exerts its tumor-suppressive function by inhibiting EGFR and its downstream pathway PMID:27599526
elevated levels of GPRC5A played significant roles in gastric cancer progression PMID:26227221
Results show how GPRC5A deficiency leads to dysregulated EGFR and STAT3 signaling and lung tumorigenesis. PMID:25744720
EGFR interacted with GPRC5A and phosphorylated it in two conserved double-tyrosine motifs, Y317/Y320 and Y347/ Y350, at the C-terminal tail of GPRC5A. PMID:25311788
The interaction of miR-103a-3p with each of the two 5' UTR targets reduces the expression levels of both GPRC5A mRNA and GPRC5A protein in one normal epithelial and two pancreatic cancer cell lines. PMID:24984703
RAI3 may contribute to the malignant progression of hepatocellular carcinoma PMID:23632812
Data indicate that in mammary tumors, the mRNA expression of GPRC5A significantly correlated with that of BRCA1. PMID:24470238
Decreased GPRC5A expression is associated with non-small cell lung cancers and lung inflammation. PMID:23154545
Loss of GPRC5A is associated with lung adenocarcinomas. PMID:20563252
RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target PMID:15659406
This evidence explains one of the mechanisms of the GPRC5A-regulated cell growth in some cancer cell lines. PMID:17055459
Gprc5a functions as a tumor suppressor in mouse lung, and human GPRC5A may share this property. PMID:18000218
Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A are reported. PMID:19279407
analysis of RAI3 expression in normal and cancerous human breast tissue at both the mRNA and protein levels PMID:19552806

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 3 family

Tissue Specificity

Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to mod

Database Links

HGNC: 9836

UNIGENE: Hs.631733

KEGG: hsa:9052

STRING: 9606.ENSP00000014914

OMIM: 604138

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