ITGA11 Antibody

Code: CSB-PA033958

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

Q9UKX5

Target Names

ITGA11

Alternative Names

integrin a11 antibody; Integrin alpha 11 antibody; Integrin alpha-11 antibody; ITA11_HUMAN antibody; ITGA11 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human ITGA11

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,WB,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA033958(ITGA11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA033958(ITGA11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse skeletal muscle tissue, Primary antibody: CSB-PA033958(ITGA11 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes

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Target Background

Function(From Uniprot)

Integrin alpha-11/beta-1 is a receptor for collagen.

Gene References into Functions

ITGA11 is a highly promising target that is selectively overexpressed in myofibroblasts during fibrotic diseases and regulates myofibroblast differentiation and key phenotypic characteristics. PMID:29147013
By employing co-immunoprecipitation and confocal microscopy analysis we showed that integrin alpha11beta1 and protein disulfide isomerase (PDI) create complexes bounded by disulfide bonds. Using surface plasmon resonance we provide biochemical evidence that PDI can interact directly with integrin subunit alpha11. PMID:29203246
Using MDR and RF, the overall best classifier of lung cancer status were SNPs rs1799732 (DRD2), rs5744256 (IL-18), rs2306022 (ITGA11) with training accuracy of 0.6592 and a testing accuracy of 0.6572 and a cross-validation consistency of 10/10 with permutation testing P<0.0001 PMID:27121382
FGF2 may be redirecting fibroblasts towards an anti-fibrotic phenotype during wound healing by overriding TGFb1 mediated ITGA11 expression. PMID:26403263
glycated collagen in the cardiac interstitium triggers an autocrine TGF-beta2 signaling pathway that stimulates alpha11 integrin expression through Smad2/3 binding elements in the alpha11 integrin promoter PMID:24962729
Myometrium and uterine fibroids express ITGA11. PMID:24520080
Interactions between alpha11 integrins and the Smad-dependent TGF-beta2 signalling may contribute to the formation of pro-fibrotic myofibroblasts and the development of a fibrotic interstitium in diabetic cardiomyopathy. PMID:22869616
The disturbance of alpha11beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2-associated X protein upregulation. PMID:21796158
Data show that the 3 kb alpha11 promoter contains most of the regulatory elements that direct ectomesenchymal and mesodermal fibroblast-specific expression. PMID:19913614
Major transcription start site mapped. A core promoter [nt (-)127-(+)25], a potential silencer region [nt (-)400-(-)127] and a potential enhancer region [nt (-)1519-(-)400] identified as important for alpha11 transcription in mesenchymal cells. PMID:12392762
the GFOGER sequence in fibrillar collagens is a common recognition motif used by integrins, particularly alpha11beta1 PMID:12496264
A new interferon stimulated gene. (Integrin alpha 11) PMID:16697656
Through interaction between matrix collagen and stromal fibroblasts, integrin alpha 11 stimulates cancer cell growth. PMID:17600088
analysis of a prokaryotic Scl1 collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1 PMID:18990704
is a major collagen receptor on human periodontal ligament cells [and plays] a role in collagen lattice remodeling [ITGA11B1] PMID:19641149

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Integrin alpha chain family

Tissue Specificity

According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small i

Database Links

HGNC: 6136

UNIGENE: Hs.436416

KEGG: hsa:22801

STRING: 9606.ENSP00000327290

OMIM: 604789

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