JAM2 Antibody

Code: CSB-PA004796

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50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: WB, ELISA

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Target Background

Product Details

Uniprot NO.

P57087

Target Names

JAM2

Alternative Names

C21orf43 antibody; CD 322 antibody; CD322 antibody; CD322 antigen antibody; JAM 2 antibody; JAM B antibody; JAM IT/VE JAM antibody; JAM; vascular endothelial antibody; JAM-2 antibody; JAM-B antibody; JAM2 antibody; JAM2_HUMAN antibody; JAMB antibody; Jcam2 antibody; Junction adhesion molecule 2 antibody; Junction adhesion molecule B antibody; Junctional adhesion molecule 2 antibody; Junctional adhesion molecule B antibody; PRO 245 antibody; PRO245 antibody; Vascular endothelial junction associated molecule antibody; Vascular endothelial junction-associated molecule antibody; VE JAM antibody; VE-JAM antibody; VEJAM antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human JAM-B.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of K562 cells using JAM-B Polyclonal Antibody

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Target Background

Function(From Uniprot)

Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons. During myogenesis, it is involved in myocyte fusion. May also play a role in angiogenesis.

Gene References into Functions

this review briefly focuses on what is currently known about the structure, function, and mechanism of JAM-B, with particular emphasis on cancer. [review] PMID:27121546
JAM-2 may function as a putative tumour suppressor in the progression and metastasis of colorectal cancer PMID:26782073
This study showed thatJAM2 (rs2829841; intronic), associated with Alzheimer disease. PMID:25649652
Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. PMID:24357068
These data brought new evidences for the role of JAM2 and JAM3 in progression of gastric adenocarcinoma PMID:23277282
role as an adhesive ligand for interacting with a variety of immune cell types PMID:11823489
interacts with alpha4beta1; Facilitation by JAM3 PMID:12070135
Results suggest a role for junctional adhesion molecule-2 (JAM-2) in facilitating transmigration in endothelial cells PMID:12476045
Examine JAM-2 expression in normal/inflammed lymphatic endothelium. PMID:17822725
Discovery as ligand for the integrin alpha4beta1 PMID:12070135
Cloning and discovery as adhesion receptor for T cells PMID:10945976

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, tight junction.

Protein Families

Immunoglobulin superfamily

Tissue Specificity

Highly expressed in heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules and also present on the endothelia of other vessels (at protein level). Also expressed in the brain in the caudate nuclei.

Database Links

HGNC: 14686

UNIGENE: Hs.517227

KEGG: hsa:58494

STRING: 9606.ENSP00000420419

OMIM: 606870

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