STAMBP Antibody

Code: CSB-PA022794GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

O95630

Target Names

STAMBP

Alternative Names

AMSH antibody; Associated molecule with the SH3 domain of STAM antibody; Endosome associated ubiquitin isopeptidase antibody; Endosome-associated ubiquitin isopeptidase antibody; MGC126516 antibody; MGC126518 antibody; MICCAP antibody; STABP_HUMAN antibody; STAM binding protein antibody; STAM-binding protein antibody; Stambp antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human STAMBP

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

Gene References into Functions

Contrary to previously reported STAMBP mutations, the Ser236Phe mutation did not lead to constitutive activation of the PI3K-AKT-mTOR pathway in patient-derived LCLs, as indicated by the expression of phosphorylated S6 ribosomal protein, suggesting that it is not the major pathomechanism underlying the disorder in this patient. PMID:29907875
Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. PMID:28492230
Two siblings with classic features of MIC-CAP syndrome that harbor a novel predicted splice mutation in STAMBP PMID:25692795
associated molecule with the SH3 domain of STAM-mediated deubiquitination of connexin 43 protects Gap junctions from degradation PMID:25070368
Recognition of the proximal ubiquitin is imperative for the linkage specificity and catalytic efficiency of AMSH. PMID:24151880
Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. PMID:23542699
AMSH efficiently removes ubiquitin from the activated EGFR. PMID:22800866
tight coupling of ESCRT-III CHMP3 and AMSH functions and provide insight into the regulation of ESCRT-III PMID:21827950
Studies indicate that USP8/Ubpy and AMSH interact with ESCRT components to modulate the ubiquitination status of receptors and relevant sorting proteins. PMID:21448666
AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. PMID:20159979
AMSH is a deubiquitinating enzyme with functions at the endosome to oppose ubiquitin-dependent receptor sorting PMID:15314065
The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM PMID:16520378
AMSH and AMSH-LP are anchored on the early endosomal membrane via interaction with the clathrin coat PMID:16716190
AMSH has a role in the deubiquitination of the endosomal cargo preceding lysosomal degradation PMID:16760479
AMSH, which has been recently characterized as a regulator of the endosomal sorting of epidermal growth factor receptor, represents a novel modulator of CaR signaling. PMID:16854379
both the deubiquitination enzyme activity of AMSH and its CHMP3-binding ability are required to clear ubiquitinated cargo from endosomes PMID:17159328
Endosomal AMSH (STAMBP) is a functional component of the multivesicular body pathway. PMID:17261583
UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY for CHMP7. PMID:17711858
crystal structures of the human AMSH-LP DUB domain alone and in complex with a Lys 63-linked di-ubiquitin at 1.2 A and 1.6 A resolutions, respectively PMID:18758443
Data suggest that AMSH and UBPY are essential for trafficking and down-regulation of PAR(2) but not for regulating PAR(2) dissociation from beta-arrestin2 or PAR(2)-mediated ERK2 activation. PMID:19684015