VDAC3 Antibody

Code: CSB-PA025827GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

Q9Y277

Target Names

VDAC3

Alternative Names

VDAC3 antibody; Voltage-dependent anion-selective channel protein 3 antibody; VDAC-3 antibody; hVDAC3 antibody; Outer mitochondrial membrane protein porin 3 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human VDAC3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

Gene References into Functions

The AG genotype of rs16891278 showed a significantly lower sperm concentration compared with the AA genotype (P = 0.044). Findings suggest that VDAC3 genetic variants may be associated with human sperm count. PMID:28431403
This cohort study showed that the VDAC3 gene was down regulation between patients with idiopathic Parkinson disease and controls PMID:28916538
VDAC3 is able to modulate its pore size and current by exploiting the mobility of the N-terminal and forming, upon external stimuli, disulfide bridges with cysteine residues located on the barrel and exposed to the inter-membrane space. PMID:26806159
channel gating of VDAC3 might be controlled by redox sensing under physiological conditions PMID:26407725
observed electrophysiological properties of hVDAC3 are surprisingly different from the other isoforms and are discussed in relation to the proposed physiological role of the protein in mammalian cells PMID:25171321
a VDAC3-Mps1 module at the centrosome promotes ciliary disassembly during cell cycle entry. PMID:23388454
VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes. PMID:22935710
VDAC3 has a limited ability to support mitochondrial respiration and has no influence in the control of ROS production. PMID:20138821
VDAC3 is a novel target for protein S-nigrosylation in spermatozoa. PMID:17683036