Recombinant Bovine Interleukin-18 (IL18)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

IL18

Purity

>85% (SDS-PAGE)

Target Names

IL18

Uniprot NO.

Q9TU73

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

37-193

Target Protein Sequence

HFGK LEPKLSIIRN LNDQVLFINQ GNQPVFEDMP DSDCSDNAPQ TIFIIYMYKD SLTRGLAVTI SVQCKKMSTL SCENKIVSFK EMNPPDNIDN EESDIIFFQR SVPGHDDKIQ FESSLYKGYF LACKKENDLF KLILKKQDDN RDKSVMFTVQ NQN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells.

Gene References into Functions

These results suggest that BAPC-1 is a stem/progenitor cell line and modulates the immuno-endocrine function of the anterior pituitary cells through its production of interleukin-18 and the IL-18 receptor. PMID:18761716

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Subcellular Location

Cytoplasm. Secreted.

Protein Families

IL-1 family

Database Links

UNIGENE: Bt.234

KEGG: bta:281249

STRING: 9913.ENSBTAP00000055793

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