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Recombinant Chicken G1/S-specific cyclin-D1 (CCND1)

Recombinant Chicken G1/S-specific cyclin-D1 (CCND1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CCND1

Uniprot NO.

P55169

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-292

Target Protein Sequence

MEHQLQCCEV ETIRRAYLDA NLLNDRVLQT MLKAEETCSP SVSYFKCVQK EILPYMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS FEPLKKSRLQ LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPDELLQM ELLLVNKLKW NLAAMTPHDF IEHFLTKMPL AEDTKQIIRK HAQTFVALCA TDVKFISNPP SMIAAGSVVA AVQGLHLGNT NTFLSYQCLT HFLSQVIKCD PDCLRACQEQ IESLLESSLR QAQQHNVSSE TKTVEDEADL SCTPTDVRDV NI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.

Gene References into Functions

motoneuron progenitors in the embryonic spinal cord persistently express Cyclin D1 during the initial phase of differentiation, while down-regulating Cyclin D2 PMID:21709239

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Cyclin family, Cyclin D subfamily

Database Links

UNIGENE: Gga.3039

KEGG: gga:396341

STRING: 9031.ENSGALP00000012203

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