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Recombinant Dog Coagulation factor VIII (F8), partial

Recombinant Dog Coagulation factor VIII (F8), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

O18806

Species

Canis lupus familiaris (Dog) (Canis familiaris)

Source

Yeast

Expression Region

20-2343

Target Protein Sequence

A TRKYYLGAVE LSWDYMQSDL LSALHADTSF SSRVPGSLPL TTSVTYRKTV FVEFTDDLFN IAKPRPPWMG LLGPTIQAEV YDTVVIVLKN MASHPVSLHA VGVSYWKASE GAEYEDQTSQ KEKEDDNVIP GESHTYVWQV LKENGPMASD PPCLTYSYFS HVDLVKDLNS GLIGALLVCK EGSLAKERTQ TLQEFVLLFA VFDEGKSWHS ETNASLTQAE AQHELHTING YVNRSLPGLT VCHKRSVYWH VIGMGTTPEV HSIFLEGHTF LVRNHRQASL EISPITFLTA QTFLMDLGQF LLFCHIPSHQ HDGMEAYVKV DSCPEEPQLR MKNNEDKDYD DGLYDSDMDV VSFDDDSSSP FIQIRSVAKK HPKTWVHYIA AEEEDWDYAP SGPTPNDRSH KNLYLNNGPQ RIGKKYKKVR FVAYTDETFK TREAIQYESG ILGPLLYGEV GDTLLIIFKN QASRPYNIYP HGINYVTPLH TGRLPKGVKH LKDMPILPGE IFKYKWTVTV EDGPTKSDPR CLTRYYSSFI NLERDLASGL IGPLLICYKE SVDQRGNQMM SDKRNVILFS VFDENRSWYL TENMQRFLPN ADVVQPHDPE FQLSNIMHSI NGYVFDNLQL SVCLHEVAYW YILSVGAQTD FLSVFFSGYT FKHKMVYEDT LTLFPFSGET VFMSMENPGL WVLGCHNSDF RNRGMTALLK VSSCNRNIDD YYEDTYEDIP TPLLNENNVI KPRSFSQNSR HPSTKEKQLK ATTTPENDIE KIDLQSGERT QLIKAQSVSS SDLLMLLGQN PTPRGLFLSD LREATDRADD HSRGAIERNK GPPEVASLRP ELRHSEDREF TPEPELQLRL NENLGTNTTV ELKKLDLKIS SSSDSLMTSP TIPSDKLAAA TEKTGSLGPP NMSVHFNSHL GTIVFGNNSS HLIQSGVPLE LSEEDNDSKL LEAPLMNIQE SSLRENVLSM ESNRLFKEER IRGPASLIKD NALFKVNISS VKTNRAPVNL TTNRKTRVAI PTLLIENSTS VWQDIMLERN TEFKEVTSLI HNETFMDRNT TALGLNHVSN KTTLSKNVEM AHQKKEDPVP LRAENPDLSS SKIPFLPDWI KTHGKNSLSS EQRPSPKQLT SLGSEKSVKD QNFLSEEKVV VGEDEFTKDT ELQEIFPNNK SIFFANLANV QENDTYNQEK KSPEEIERKE KLTQENVALP QAHTMIGTKN FLKNLFLLST KQNVAGLEEQ PYTPILQDTR SLNDSPHSEG IHMANFSKIR EEANLEGLGN QTNQMVERFP STTRMSSNAS QHVITQRGKR SLKQPRLSQG EIKFERKVIA NDTSTQWSKN MNYLAQGTLT QIEYNEKEKR AITQSPLSDC SMRNHVTIQM NDSALPVAKE SASPSVRHTD LTKIPSQHNS SHLPASACNY TFRERTSGVQ EGSHFLQEAK RNNLSLAFVT LGITEGQGKF SSLGKSATNQ PMYKKLENTV LLQPGLSETS DKVELLSQVH VDQEDSFPTK TSNDSPGHLD LMGKIFLQKT QGPVKMNKTN SPGKVPFLKW ATESSEKIPS KLLGVLAWDN HYDTQIPSEE WKSQKKSQTN TAFKRKDTIL PLGPCENNDS TAAINEGQDK PQREAMWAKQ GEPGRLCSQN PPVSKHHQRE ITVTTLQPEE DKFEYDDTFS IEMKREDFDI YGDYENQGLR SFQKKTRHYF IAAVERLWDY GMSRSPHILR NRAQSGDVQQ FKKVVFQEFT DGSFTQPLYR GELNEHLGLL GPYIRAEVED NIVVTFKNQA SRPYSFYSSL ISYDEDEGQG AEPRRKFVNP NETKIYFWKV QHHMAPTKDE FDCKAWAYFS DVDLEKDVHS GLIGPLLICR SNTLNPAHGR QVTVQEFALV FTIFDETKSW YFTENLERNC RAPCNVQKED PTLKENFRFH AINGYVKDTL PGLVMAQDQK VRWYLLSMGS NENIHSIHFS GHVFTVRKKE EYKMAVYNLY PGVFETVEML PSQVGIWRIE CLIGEHLQAG MSTLFLVYSK KCQTPLGMAS GHIRDFQITA SGQYGQWAPK LARLHYSGSI NAWSTKDPFS WIKVDLLAPM IIHGIMTQGA RQKFSSLYVS QFIIMYSLDG NKWHSYRGNS TGTLMVFFGN VDSSGIKHNI FNPPIIAQYI RLHPTHYSIR STLRMELLGC DFNSCSMPLG MESKAISDAQ ITASSYLSSM LATWSPSQAR LHLQGRTNAW RPQANNPKEW LQVDFRKTMK VTGITTQGVK SLLISMYVKE FLISSSQDGH NWTLFLQNGK VKVFQGNRDS STPVRNRLEP PLVARYVRLH PQSWAHHIAL RLEVLGCDTQ QPA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.

Gene References into Functions

Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response PMID:24829206
Recombinant canine B-domain deleted (BDD) factor VIII (FVIII) is predominantly expressed as a single-chain protein and exhibits greater stability after activation compared with human FVIII-BDD. PMID:23372167

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Subcellular Location

Secreted, extracellular space.

Protein Families

Multicopper oxidase family

Database Links

UNIGENE: Cfa.3740

KEGG: cfa:403875

STRING: 9615.ENSCAFP00000029035

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