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Recombinant Drosophila melanogaster Ras-related protein Rab-3 (Rab3)

Recombinant Drosophila melanogaster Ras-related protein Rab-3 (Rab3)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Rab3

Uniprot NO.

P25228

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-220

Target Protein Sequence

MASGGDPKWQ KDAADQNFDY MFKLLIIGNS SVGKTSFLFR YADDSFTSAF VSTVGIDFKV KTVFRHDKRV KLQIWDTAGQ ERYRTITTAY YRGAMGFILM YDVTNEDSFN SVQDWVTQIK TYSWDNAQVI LVGNKCDMED QRVISFERGR QLADQLGVEF FETSAKENVN VKAVFERLVD IICDKMSESL DADPTLVGGG QKGQRLTDQP QGTPNANCNC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Gene References into Functions

This study demonstrated that the Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction. PMID:27022630
Findings suggest that Rab3 controls the distribution of active zone components via a vesicle docking mechanism that is consistent with standard Rab protein function. PMID:26317909
Rab3 regulates basal synaptic strength and short-term plasticity at the level of release probability at individual sites. PMID:21378971
The data of this study defined roles for Rab3-GAP and Rab3 in synaptic homeostasis and uncover a mechanism, acting at a late stage of vesicle release, that opposes the progression of homeostatic plasticity. PMID:21338884
This study showed that the small GTPase Rab3 controls the protein composition and release probability of individual active zones at the Drosophila neuromuscular junction. PMID:20005823