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Recombinant Drosophila melanogaster Ras-related protein Ral-a (Rala)

Recombinant Drosophila melanogaster Ras-related protein Ral-a (Rala)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Rala

Uniprot NO.

P48555

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-198

Target Protein Sequence

MSKKPTAGPA LHKVIMVGSG GVGKSALTLQ FMYDEFVEDY EPTKADSYRK KVVLDGEEVQ IDILDTAGQE DYAAIRDNYF RSGEGFLCVF SITDDESFQA TQEFREQILR VKNDESIPFL LVGNKCDLND KRKVPLSECQ LRAQQWAVPY VETSAKTREN VDKVFFDLMR EIRSRKTEDS KATSGRAKDR CKKRRLKC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Gene References into Functions

data indicate that Ral and the exocyst regulate autophagy in a context-dependent manner, and that in dying salivary glands, Ral mediates autophagy, at least in part, by regulation of Notch. PMID:26598552
These studies identify a pathway, which stretches from Rab8 to RalA and the exocyst complex, that mediates rapid furrow formation in early Drosophila embryos. PMID:26092850
Constitutively active Ral expressed in muscle causes the exocyst to be concentrated in the region surrounding synaptic boutons and consequently enlarges the membrane folds of the postsynaptic plasma membrane. PMID:23812009
the Rap1-Rgl-Ral signaling network is a novel mechanism that cooperates with other intrinsic polarity cues to modulate asymmetric neuroblast division PMID:22084305
prevention of ligand-independent Notch activation is not simply a constitutive process, but is a target for regulation by Ral during cell fate specification and pattern formation. PMID:21350007
Abnormalities of the Wnt5/5a pathway (located in the apical ectodermal ridge as well as in the mesoderm) will affect chondrogenesis of the developing limb and experimental Wnt5a(-/-) limbs have terminal adactyly. PMID:20709709
the Ral-centered protein network appears to be extremely conserved in human and flies PMID:12529414
The identification and characterization of a DBL-like guanine nucleotide exchange factor (GEF) in Drosophila, called GEFmeso, as a novel binding target of the Ras-like GTPase Ral. PMID:16581976
RalA is required in organizing centres to control proper patterning and migration in vivo. PMID:18552769