Recombinant Human Anoctamin-6 (ANO6), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

ANO6

Purity

>85% (SDS-PAGE)

Target Names

ANO6

Uniprot NO.

Q4KMQ2

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.; Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.

Gene References into Functions

ICl,Swell, and cell volume are regulated by Ano6. The findings suggest a novel clinically-relevant approach for altering cell volume, and thereby outflow resistance, by targeting Ano6. PMID:28125837
TMEM16F modifies viability of Human Embryonic Kidney cells via its function as a phospholipid scramblase and activation of AKT signaling pathways. PMID:27287741
Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms PMID:26108457
deficiency in Ano6 resulted in reduced viability with increased bleeding time PMID:26481309
ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys. PMID:26448322
Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets. PMID:26057829
Ano6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. PMID:25651887
using human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix PMID:25589784
Anoo6 induces a chloride ion conductance along with a smaller nonselective cation conductance that is activated either calcium ion dependently (ionomycin) or calcium independently(fas receptor), but not during mitochondrial apoptosis. PMID:23618909
a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population PMID:23308121
TMEM16F is an essential component of a divalent calcium ion-activated Cl- channel with a divalent calcium ion sensitivity that is distinct from that of TMEM16A/B and not related to volume-sensitive outwardly rectifying Cl- channel (VSOR) activity. PMID:23426967
It scrambles phospholipids in cell membrane and its mutation leads to Scott syndrome. (review) PMID:22256604
Study identified 2 novel mutations in the TMEM16F gene in 2 patients with Scott syndrome. PMID:21511967
Wild-type TMEM16F was localized on the plasma membrane and conferred Ca(2+)-dependent scrambling of phospholipids PMID:21107324