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Recombinant Human Growth arrest-specific protein 1 (GAS1)

Recombinant Human Growth arrest-specific protein 1 (GAS1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

GAS1

Uniprot NO.

P54826

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

40-318

Target Protein Sequence

L AHGRRLICWQ ALLQCQGEPE CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS SRWRCPSHCI SALIQLNHTR RGPALEDCDC AQDENCKSTK RAIEPCLPRT SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN LALSRYLTYC GKVFNGLRCT DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA RLCFGAELGN GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA AASGGRGDLP YGPGRRSS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.

Gene References into Functions

Studies establish Gas1 as a negative regulator in colorectal cancer. PMID:27401611
These results demonstrated that miR-184 and the GAS1/Akt pathway may be a potential therapeutic target for intervertebral disc degeneration. PMID:26805687
WT1 modulates Akt/JNK signaling pathway mediated autophagy by controlling the expression of growth arrest-specific 1 (Gas1). PMID:27453337
Downregulation of GAS1 is associated with clear cell renal cell carcinoma. PMID:28184927
the synergistic effect of Gas1 inhibition and GDNF against glutamate-induced cell injury in human SH-SY5Y neuroblastoma cells, is reported. PMID:26215053
solutions structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1 PMID:25888394
This review summarizes the structure of Gas1 and molecular mechanism of action during embryonic development and cellular functions. PMID:25429664
GAS1 is a novel endogenous inhibitor of glomerular mesangial cell proliferation. PMID:23254899
Growth arrest-specific gene 1 is downregulated and inhibits tumor growth in gastric cancer. PMID:22846196
GAS1 induced the activity of caspase-3 and resulting in apoptosis of the cells. PMID:22311470
Interference of endoplasmic reticulum to Golgi transport increased immature amyloid beta protein precursor accumulation upon Gas1 expression in lipid raft fractions. PMID:21971401
we demonstrate that sequence variants in GAS1 can impair its physical interaction with SHH, suggesting a decrease in the SHH downstream signaling cascade as a pathogenic mechanism of disease. PMID:21842183
Gas1 is a novel APP-interacting protein involved in the control of APP maturation and processing. PMID:21357679
Growth arrest-specific gene 1 contributes to predicting metastasis or recurrence in stage II and III colorectal cancer. PMID:21111449
GAS1 could be considered a candidate locus for one of the types of human holoprosencephaly. PMID:20583177
Gas1 is related to the GDNF alpha receptors and regulates Ret signaling PMID:16551639
This review considers the possible involvement of GAS1 in genetic diseases, stem cell renewal, and cancer growth through its cooperative activity with Hedgehog (HH) growth factor and the HH receptor. PMID:17726382
Gas1 is a molecule involved in cell arrest that can induce apoptosis when over-expressed in different cell lines. PMID:18394855
Gas1 has all the expected properties of a melanoma tumor suppressor: suppression of metastasis in a spontaneous metastasis assay, promotion of apoptosis following dissemination of cells to secondary sites, and down-regulation in human melanoma metastasis. PMID:18981472
Results present evidence demonstrating that Gas1 exerts its effects inhibiting cell growth and inducing apoptosis of glioma cells in the absence of Shh. PMID:19460624
Results suggest that GAS1 might be a target to overcome multidrug resistance and provide a novel approach to identifying candidate genes that suppress chemoresistance of gastric cancers. PMID:19638344
GAS1 is preferentially expressed by human bulge cells, compared to differentiated hair follicle keratinocytes PMID:20050020