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Recombinant Human Growth/differentiation factor 7 (GDF7)

Recombinant Human Growth/differentiation factor 7 (GDF7)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

GDF7

Purity

>85% (SDS-PAGE)

Target Names

GDF7

Uniprot NO.

Q7Z4P5

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

322-450

Target Protein Sequence

TALAGTRTA QGSGGGAGRG HGRRGRSRCS RKPLHVDFKE LGWDDWIIAP LDYEAYHCEG LCDFPLRSHL EPTNHAIIQT LLNSMAPDAA PASCCVPARL SPISILYIDA ANNVVYKQYE DMVVEACGCR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May play an active role in the motor area of the primate neocortex.

Gene References into Functions

BMP-12 activates tenogenic pathway in human adipose stem cells. PMID:28214472
The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk. PMID:26783083
closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development PMID:25447851
BMP12 induces tenogenic differentiation of adipose-derived stromal cells via the Smad1/5/8 pathway. PMID:24155967
studies show that even though tenogenic (BMP 12 and BMP 13) and osteogenic (BMP2) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers PMID:21702718
induces ligamentogenic differentiation in mesenchymal progenitors PMID:20334610
stimulates expression of both chondrogenic and osteoblstic markers in pluripotent mesenchymal C3H10T1/2 cells. PMID:20102312
In mouse, the expression of Gdf7 in roof plate cells is required for the fidelity of commissural axon growth. PMID:12741987