Recombinant Human T-cell antigen CD7 (CD7)

1. in acute myeloid leukemia patients the association of CD7 positivity and FLT3 positivity was found to be significant PMID:25679063
2. Data show that CD7 promotes extramedullary involvement of the B-ALL line Tanoue in an integrin beta2-dependent manner. PMID:24920488
3. We showed that the CADM1 versus CD7 plot is capable of discriminating clonally expanding HTLV-I-infected cells in indolent and acute-type T-cell leukemia-lymphomas and in asymptomatic carriers PMID:24727323
4. CD7 is present on monocytes and tumor macrophages and its ligand, SECTM1, is frequently expressed in corresponding melanoma tissues PMID:24157461
5. SECTM1 secreted from bone marrow stromal cells may interact with CD7 to influence GM-CSF expression in leukemic cells. PMID:24211252
6. epigenetic down-regulation of CD7 is associated with acute myeloid leukemia. PMID:20398252
7. CD7 loss in aggressive natural killer-cell leukemia; a useful diagnostic marker PMID:20046078
8. low expression in T-cell lymphomas due to Twist2-mediated suppression of promoter activity; enhanced by histone deacetylase inhibitors PMID:19937140
9. These findings indicate a link between epigenetic modifications and CD7 expression in primitive chronic myeloid leukemia cells. PMID:20175919
10. CD7 expression in hematopoitic cells denotes commitment to B-cell and natural killer cells lineages. PMID:12393702
11. Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover. PMID:12594831
12. a novel fusion protein, designated scFvCD7:sFasL is designed to have leukemia-restricted activity. PMID:16332967
13. Patients expressing CD7 had significant shorter disease free (DFS) and post-remission survivals (PRS) than patients without CD7 (DFS of 12 months versus 42 months, P=0.005; PRS of 15 months versus 33 months, P=0.013). PMID:16837044
14. CD7 antigen notably expresses in lung microvascular endothelial cells (LME) and that it acts as an Fc receptor for IgM in LME cells. PMID:16990185
15. HTLV-IInfected cells acquired a profound decrease of intracellular calcium levels in response to ionomycin, timely correlated with decreased CD7 expression PMID:17287851
16. differential levels of CD7 identify the progressive stages of lineage commitment in human thymus, initiated from a primitive CD7(-) lympho-myeloid thymic progenitor PMID:17959857
17. close association of aberrant CD7 expression and FLT3/ITD mutation in the myeloblasts of FLT3/ITD+ acute myeloid leukemia suggests that FLT3/ITD- mediated leukemic transformation occurs in the more early stage of myeloid progenitor cells PMID:18343790
18. The CD7 expression in CD4(+) T cells discriminates between HL and reactive LAD, suggesting that this could be a useful and practical adjunctive tool in the diagnosis of Hodgkin lymphoma. PMID:18956470
19. by down-regulating CD7, ATLL cells could have escaped Gal-3-induced apoptosis to run a more aggressive clinical course PMID:19207946
20. the galectin-1 glycoprotein receptor CD7 maybe a novel target for GdA on T cells. PMID:19683346

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HGNC: 1695

UNIGENE: Hs.36972

KEGG: hsa:924

STRING: 9606.ENSP00000312027

OMIM: 186820