Recombinant Mouse Anoctamin-6 (Ano6), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Ano6

Purity

>85% (SDS-PAGE)

Target Names

Ano6

Uniprot NO.

Q6P9J9

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.

Gene References into Functions

TMEM16F knockout did not affect Ca2+ signaling and Ca2+-activated whole cell currents in podocytes. TMEM16F shows little effect on basal properties of podocytes and does not appear to be essential for renal function. PMID:29912162
TMEM16F interaction with phosphatidylinositol-(4, 5)-bisphosphate works synergistically with membrane depolarization to facilitate Ca(2+)-gating of TMEM16F. PMID:29382763
TMEM16F is an essential component of the microglial response to injury and suggest the importance of microglial phagocytosis in the pathogenesis of neuropathic pain. PMID:27332874
The present data demonstrate the activation of ANO6 during necroptosis, which, however, is not essential for cell death. PMID:27535660
TMEM16F deficiency results in sustained signaling and augmented T cell activation. PMID:27810927
Platelet TMEM16F activity contributes significantly to hemostasis and thrombosis but not cerebral thromboinflammation. PMID:27634832
ANO6 produces volume-regulated anion currents and controls cell volume in four unrelated cell types. PMID:26438191
deficiency in Ano6 resulted in reduced viability with increased bleeding time PMID:26481309
Although broadly expressed, Ano6 has no role in intestinal cholinergic Cl- secretion. PMID:24974903
Ano6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. PMID:25651887
TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets. PMID:26417084
Ano6 and Ano2 proteins co-localize in the ciliary membrane microdomains, which indicates a role for Ano6 in olfactory signaling. PMID:25500808
human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix PMID:25589784
Ano6 plays an essential role in C2C12 myoblast proliferation PMID:24663380
The mTMEM16F-associated ICl,Ca was abolished in one mutant of the putative pore region (R592E. PMID:23630341
In primary Ano6(-/-) osteoblasts, mineralization is delayed, indicating a cell autonomous function of Ano6. PMID:22936354
TMEM16F forms a SCAN channel with considerable Ca2+ selectivity-an unprecedented finding of a cation channel as a closely related family member of anion channels; loss of TMEM16F function greatly reduced the propensity to thrombosis. PMID:23021219
Data show the expression of Tmem16f during murine embryogenesis with an emphasis on the respiratory, digestive, skeletal, and integumentary systems. PMID:18729231
during mouse cephalic development: detected in subventricular zone and differentiating fields, in rostral spinal cord motor neuron area, stria vascularis,in submandibular autonomic ganglia, in palate, tooth and tongue, and in osteoblasts and chondrocytes PMID:19059364