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Recombinant Mouse CDK5 regulatory subunit-associated protein 2 (Cdk5rap2), partial

Recombinant Mouse CDK5 regulatory subunit-associated protein 2 (Cdk5rap2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Cdk5rap2

Purity

>85% (SDS-PAGE)

Target Names

Cdk5rap2

Uniprot NO.

Q8K389

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-1822

Target Protein Sequence

MDSGMEEEGA LPGTLSGCSG LHPVLPSDLD VISDTSGLGN GVLPSMSEEK VSPTRARNMK DFENQITELK KENFNLKLRI YFLEERIQQE FAGPTEHIYK TNIELKVEVE SLKRELQEKD QLLVKASKAV ESLAERGGSE VQRVKEDARK KVQQVEDLLT KRIHLLEEDV KAAQAELEKA FAGTETEKAL RLSLESKLSA MKKMQEGDLE MTLALEEKDR LIEELKLSLK SKEALIQCLK EEKSQMASPD ENVSSGELRG LSATLREEKE RDAEEWQKER NHFEERIQAL QEDLREKERE IATEKKNNLK SYKAIQGLTM ALKSKEREVE ELDSKIKEVT TDSTKGREDP LKTQIPRFQL REGSEDCEAA LVEKEALLAK LHSENVTKST ENHRLLRNVK KVTQELNDLK KEKLRLEQAL EEAHQEGNRG ARTIHDLRNE VEKLRKEVSE REKAVEKHYK SLPGESKTKF HTQEQVVRSL TGSGSQEDLL LQKSNEKDLE AIQQNCYLMT AEELKFGSDG LITEKCSQQS PDSKLIFSKE KQQSEYEGLT GDLKAEQNIY AHLAKTQDTD SVSNLQAELK EVLALRKQLE QDVLAYRNLQ KALQEQLSEI RSREEEPFSF YSDQTSYLSI CLEEHNQFQL EHFSQEELKK KVSDLIQLVK DLHTDNQHLK KTIFDLSSVG FQGSDRLELT KQEELVASKE DEDTLKFEAD VETPFQSDQH LEQSREIMED YAEGGCKSGY GRHMDSNILG HDGAQTPGAS EEHTLEDELL GLLATLFSKK ATPLLESRPD LLKALGALLL ERICLAEQGR PGDHLDSKTE KALQQVAVQL RDELGHSFPA NSFSKSYNEV KSMWGNWLVK TGDEDTVELK SVSVQTMAIE DTPHGFKPQS KRDAWAEKQE EAIFSTELES EALGEMPGQQ ATHLSFPSAI NPDAEKTGLL IQLKTPELLE NLYNLPASPE VVVAQLQGQV LELQRELKEF KTRNKQLHEK LILAEAMMEG LPVPNSALVN VPAAQAVVRT AFQDNPGEQE GPETTQSAGR DKDMDSDQYT SFEIDSEICP PDDLALLPAC KENLEDLLGP SSIATYLDSK SQLSVKVSVN GTDQSENINI PDDTEDLKQK IHDLQTELEG YRNIIVQLLK HSQCSEAIIT VLCGTEGAQD GLNKPKGHID EEEMTFSSLH QVRYVKHMKI LRPLTPEMID GKMLESLKQQ LVDQEQELQK EQDLNLELFG EIHDLQNKFQ DLSPSRYDSL VQSQARELSL QRQQIKDSHG ICVIYRQHMS TMIKAFEELL QASDVDSCVA EGFREQLTQC AGLLEQLERL FLHGKSARVE PHPQNELLKG LRTVEGNLPY HHLLPESPEP SASHALSDDE MSEKSFLSRD PKPDSDTEKY PAMASHFPQD LLMEHIQEIR TLRKHLEESI KTNEKLRKQL ERQGSETDQG SRNVSACGLA LHSSLTSEIH FLRKQNEALS MMLEKGSKDK QKESEKLRES LARKAESLEQ LQLEYTSVRE ENERLQRDII EKERHNQELT EEVCSSRQEL SRVQEEAKSR QQLLSQKDKL LQSLQMELKV YEKLAEEHPR LQQDGSKCPE ASDNSFDLFE STQAMAPKSA SETPLLSGTD VDSLSCDSTS SATSPTSMPC LVAGHHMWAS KSGHHMLGLI EDYDALYKQI SWGQTLLAKM DVQTQEALSP TSHKLGPKGS SSVPLSKFLS SMNTAKLVLE KASRLLKLFW RVSVPTNGQC SLHCEQIGEM KAENTKLHKK LFEQEKKLQN TAKLLQQSKH QEKVIFDQLV ITHQVLRKAR GNLELRPGAT RPGASSPSRP GS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Required for the recruitment of AKAP9 to centrosomes. Plays a role in neurogenesis. Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear.

Gene References into Functions

We highlight that infertility in Cdk5rap2 mutant mice is secondary to a lack of spermatogenic cells in adult mice as a result of an early developmental defect in the germ cells through mitotic delay, prolonged cell cycle, and apoptosis. PMID:28162995
mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms PMID:26550838
this study revealed the presence of previously unknown splice variants of the Cdk5rap2 gene that are at least in part accountable for the lack of microcephaly in the mice. PMID:26322982
In Cdk5rap2-depleted neural embryonic stem cells there is an increase in cell death in differentiating cells. PMID:25942099
Mouse expression pattern of CDK5RAP2 is similar to that seen in humans and is in concordance with pathology suggested by neuroimaging studies in humans and mouse PMID:22806269
This study demonistrated that CDK5RAP2 is a key molecule that mediates functional interaction and is essential for centrosomal targeting of Aurora-A. PMID:22875938
These results indicate that CDK5RAP2 is required to maintain centriole engagement and cohesion, thereby restricting centriole replication. PMID:20627074
Cdk5rap2 is highly expressed in the neural progenitor pool and its loss results in a depletion of apical progenitors and increased cell-cycle exit leading to premature neuronal differentiation PMID:20471352
The an mutation is a genomic inversion of exon 4 of Cdk5rap2, resulting in an in-frame deletion of exon 4 from the mRNA. Cdk5rap2(an/an) neuronal precursors exit the cell cycle prematurely and many undergo apoptosis. PMID:20460369