Recombinant Mouse Caveolin-2 (Cav2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Cav2

Purity

>85% (SDS-PAGE)

Target Names

Cav2

Uniprot NO.

Q9WVC3

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-162

Target Protein Sequence

MGLETEKADV QLFMADDAYS HHSGVDYADP EKYVDSSHDR DPHQLNSHLK LGFEDLIAEP ETTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA GILFATLSCL HIWILMPFVK TCLMVLPSVQ TIWKSVTDVV IGPLCTSVGR SFSSVSMQLS HD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.

Gene References into Functions

While structural and functional properties of resistance networks are well maintained in the gluteus muscle of Cav2(-/-) mice, diminished rapid onset vasodilation with greater force production reveals novel physiological roles for Cav2 in skeletal muscle. PMID:27317631
We concluded that caveolin-2 is most probably involved in regulation of pro-inflammatory responses of BMDMs, triggered via activation of ERK1/2. PMID:26215374
Cav-2 expressed in tumor microenvironment may potentially become a novel target for cancer therapy PMID:25269481
In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta compared to empty vector. PMID:22819829
Data show that the balance between caveolin-1 and caveolin-2 is important for iNOS expression and ultimately for sepsis outcome. PMID:21670588
The negative regulation of transforming growth factor-beta1 signaling and function by caveolin 2 is independent of caveolin 1 expression levels and is not because of changing targeting of caveolin 1 protein to plasma membrane lipid raft/caveolar domains. PMID:21832243
Data suggest that Cav-2 negatively regulates lung endothelial cell proliferation and cell cycle progression. PMID:20007452
Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae PMID:11884617
Splice variant of mouse caveolin-2 mRNA, encoding an isoform lacking the C-terminal domain, localized to the endoplasmic reticulum, while the authentic caveolin-2 was distributed to the Golgi and the plasma membrane along with caveolin-1. PMID:12054493
Src-induced phosphorylation of caveolin-2 on tyrosine 19. PMID:12091389
lipid raft-dependent tyrosine phosphorylation of caveolin-2 may be a critical regulator of P. aeruginosa invasion PMID:15545264
molecular complex most likely to obstruct RACK1 for functional attachment at syndecan-2, as revealed in cells transfected with oncogenic ras PMID:16997272
skeletal muscle fibers from male Cav-2(-/-) mice show striking abnormalities, such as tubular aggregates, mitochondrial proliferation/aggregation, and increased numbers of M-cadherin-positive satellite cells PMID:17200204

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Subcellular Location

Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.

Protein Families

Caveolin family

Database Links

UNIGENE: Mm.396075

KEGG: mmu:12390

STRING: 10090.ENSMUSP00000000058

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