Recombinant Mouse Desert hedgehog protein (Dhh), partial

1. the critical role of Dhh in maintaining blood nerve barrier integrity and demonstrates for the first time that endothelial dysfunction is sufficient to induce neuropathy PMID:26645982
2. In organogenesis of the ovary, production of Dhh/Ihh in granulosa cells requires growth differentiation factor 9 from the oocyte. PMID:25917826
3. increased expression in cell bodies of cutaneous sensory nerves of dorsal root ganglia as compared with skin epithelia PMID:25842978
4. The results demonstrate a pivotal role for dhh in maintof this study aining myelination. Furthermore, dhh signaling reveals a potential target for therapeutic intervention to prevent and treat demyelination of peripheral nerves in compression neuropathies PMID:25936873
5. Hedgehog signaling is impaired in aged mice. Hegdehog-dependent regulation of angiogenesis and myogenesis involves distinct mechanisms. PMID:24135022
6. Data indicate that the centrosomal protein DZIP1 interacts with GLI3 transcription factor in the cytoplasm and regulates Hedgehog signaling and ciliogenesis. PMID:23955340
7. Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. PMID:23343527
8. Desert hedgehog-dependent transcription in T cells promotes T helper (Th)2 cell transcriptional programs and differentiation, exacerbating allergic disease. PMID:23408837
9. During recovery of hematopoiesis after irradiation, and under conditions of stress-induced erythropoiesis, erythrocyte differentiation was accelerated in both spleen and bone marrow of Dhh-deficient mice compared with wild type. PMID:22461491
10. The findings suggest that Sertoli cells coordinate Dhh-dependent spermatogenesis events via Ptc1 and Smo prior to the first meiotic division and in postmeiotic (haploid) cells, particularly during the first half of spermiogenesis. PMID:19484749
11. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis PMID:12050120
12. transgenic skin developed lesions reminiscent of human basal cell carcinoma PMID:15371305
13. Prominent role of hedgehog signaling in the communication between granulosa cells and developing theca cells. PMID:15878962
14. A single identified glial signal, desert hedgehog, plays a critical role in controlling the integrity of peripheral nervous tissue, in line with its critical role in nerve sheath development. PMID:16763045
15. results demonstrate a functional desert hedgehog(HH) pathway in the follicle and identify granulosa cells as at least one of the potential targets of HH signaling PMID:17392501
16. combinatorial expression of the paracrine factor Dhh and nuclear transcription factor Sf1 is required for Leydig cell development PMID:17495005
17. Inactivation of Nf1 in the glial lineage in vitro at embryonic day 12.5 + 1, but not earlier (neural crest) or later (mature Schwann cell), results in colony-forming cells capable of multilineage differentiation. PMID:18242511

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UNIGENE: Mm.324688

KEGG: mmu:13363

STRING: 10090.ENSMUSP00000023737