Recombinant Mouse Growth arrest-specific protein 1 (Gas1)

1. that Gas1 is a direct target of NeuroD1 during the induction of the neurogenic program PMID:29395133
2. Gas1 is expressed and released by neurons and promotes differentiation PMID:29110208
3. Western blot and immunofluorescence analyses showed two GIP-anchored proteins were clearly involved in the fertilisation process, namely growth arrest specific 1 (Gas1) and glial cell line-derived neurotrophic factor receptor alpha1 (Gfralpha1). This was demonstrated by evaluating oocyte fertilisability after treatment of oocytes with antibodies against the selected proteins, with their respective short interference RN... PMID:28442042
4. Findings provide evidence for a dual requirement for Boc and Gas1 during early development of the palate, mediating cell cycle regulation during growth and subsequent fusion of the palatal shelves. PMID:27811357
5. The results suggest that in diabetes the decrease of Gas1 promotes the activation of parietal progenitor cells of Bowman's capsule that might differentiate into podocytes and compensate their loss observed in this pathology. PMID:28315934
6. Up-regulation of inducible Gas1 contributed to the apoptosis of reactive astrocytes in injured substantia nigra. PMID:27391369
7. The C/EBP target Gas1 is induced in granulosa cells and is associated with ovulation and luteinization. PMID:26740594
8. the overexpression of Gas1 (growth arrest specific 1) gene reduces the size, proliferating activity and malignancy of liver tumors. PMID:26161998
9. WT1 modulates receptor tyrosine kinase signaling in nephron progenitor cell by directing the expression of Gas1. PMID:25804736
10. When Shh is presented as a point source, enteric axons turn away from it in a Gas1-dependent manner. PMID:25535338
11. We demonstrated that tGas1 has an antineoplastic effect, and the results support the potential of tGas1 as an adjuvant for the treatment of gliomas PMID:24529556
12. widespread distribution and cellular localization of the GAS1 native protein in adult mammalian CNS PMID:23813868
13. finding that Gas1 is transcribed at the G(1)/S transition suggests that the gene may exert a novel function during cell proliferation. PMID:21858068
14. Gas1 promotes myogenic differentiation through regulation of cell cycle arrest and is critical to activate p38MAPK PMID:21820049
15. Genetic loss-of-function of GAS1, CDO, and BOC in SHH is associated with defective neural patterning. PMID:21664576
16. Gas1 is related to the GDNF alpha receptors and regulates Ret signaling PMID:16551639
17. GAS1 acts cooperatively with Patched1 for Hedgehog binding and enhances signaling activity in a cell-autonomous manner. PMID:17504940
18. Gas1 and Cdo cooperate to promote Shh signaling during neural tube patterning, craniofacial, and vertebral development PMID:17504941
19. Loss of a single Shh allele in a Gas1(-/-) background significantly exacerbated the midline craniofacial phenotype, providing genetic evidence that Shh and Gas1 interact. PMID:17525797
20. Gas1 has all the expected properties of a melanoma tumor suppressor: suppression of metastasis in a spontaneous metastasis assay, promotion of apoptosis following dissemination of cells to secondary sites, and down-regulation in human melanoma metastasis. PMID:18981472
21. Results provide evidence that HPE associated with this mutation can be mechanistically explained by a severely reduced binding of SHH to GAS1. PMID:19478089

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UNIGENE: Mm.22701

KEGG: mmu:14451

STRING: 10090.ENSMUSP00000064555