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Recombinant Mouse Histone-lysine N-methyltransferase MLL2 (Mll2), partial

Recombinant Mouse Histone-lysine N-methyltransferase MLL2 (Mll2), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Mll2

Purity

>85% (SDS-PAGE)

Target Names

Kmt2d

Uniprot NO.

Q6PDK2

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-5588

Target Protein Sequence

MDSQKPPAED KDSDPAADGL AAPEKPGATE PDLPILCIGE VSVPGSGGSR PQKPPHDCSR GPARRCALCN CGEPGLHGQR ELQRFELPSD WPGFPVVPSG GNSGPCEAVL PKEDASQIGF PEGLTPAHLG EPGGHCWAHH WCAAWSAGVW GQEGPELCGV DKAIFSGISQ RCSHCARFGA SVPCRSPGCS RLYHFPCATA SGSFLSMKTL QLLCPEHSDG AAHLEEARCA VCEGPGQLCD LLFCTSCGHH YHGACLDTAL TARKRASWQC PECKVCQSCR KPGNDSKMLV CETCDKGYHT FCLKPPMEDL PAHSWKCKTC RLCRACGAGS AELNPNSEWF ENYSLCHRCH KAQGSQPVTS VAEQHPAVCS RLSPPEPGEI PIDAPDALYV ACQGQPKGGH VTSMQPKELA PLQCEAKPLG RAGTQLEAQL EAPLHEEMPL LPPPEESPLS PPPEESPTSP PPEASRLSPP TEESPLSPPP ESSPFSPLEG CPPSPALDTP LSPPPEASPL SPPFEESPLS PPPEELPSSP PPEASRLSPP PEESPMSPPP EESPMSPPPE ASRLFPPFEE SPLSPPPEDS PLSPPPEASR LSPPPEDSPM SPPPEDSPMS PPPEVSRFLP LPVLSHLSPL PEVSRLSPPP EESPLSPPPE DSPASPPPEA SRLSPPPEDS PASPPPEASR LSRPREDSPA SPPPEDSLVS LPMEESPLSP LPEELRLCPQ PEEPYLSPQP EEPRLCPQPE ELPLSPQSEE PCLSPVLVEP GPSSQPEEPH LSPVPQEPHL SPQPEEPHLS PQPQQLHLSP HSEEPCLSPM PEEPCLSPQP EELNGPPQPA EPPEEPSQSS APKELSLFSP SGEPPLPPML GEPALSEPGE PPLSPLPEEL PLSLSGEPVL SPQLMPPDPL PPPLSPIIPA AAPPALSPLG ELEYPFGAKG DSDPESPLAA PILETPISPP PEANCTDPEP VPPMILPPSP GSPLGPASPI LMERLPPPCS PLLPHSLPPP TPPPSHCSPP ALPLSVPSPL SPVQKAVDVS DEAELHEMET DKGPEPECPA LEPRATSPLP SPLGDLSCPA PSPAPALDDF SGLGEDTAPL DGTGQMSGSL AGELKGSPVL LDPEELTPVT PMEVYGPECK QAGQGSPCEE QEEPGAPMAP MPPTLIKSDI VNEISNLSQG DASASFPGSE PLLGSPDPEG GGSLSMELGV STDVSPARDE GSLRLCTDSL PETDDSLLCD TGTATSGGKA EGDKGRRRSS PARSRIKQGR SSSFPGRRRP RGGAAHGGRG RGRARLKSTT SSVETLVADI DSSPSKEEEE EDDDTMQNTV VLFSNTDKFV LMQDMCVVCG SFGRGAEGHL LACSQCSQCY HPYCVNSKIT KVMLLKGWRC VECIVCEVCG QASDPSRLLL CDDCDISYHT YCLDPPLLTV PKGGWKCKWC VSCMQCGAAS PGFHCEWQNS YTHCGPCASL VTCPVCHAPY VEEDLLIQCR HCERWMHAGC ESLFTEDEVE QAADEGFDCV SCQPYVVKPV VPVAPPELVP VKVKEPEPQF FRFEGVWLTE TGMAVLRNLT MSPLHKRRQR RGRLGLPGEA GLEGSEPSDA LGPDDKKDGD LDTDDLLKGE GGVEQMECEI KLEGPASPDV ELGKEETEES KKRKRKPYRP GIGGFMVRQR KSHTRVKRGP AAQAEVLSGD GQPDEVMPAD LPAEGSVEQS LAEGDEKKKQ QRRARKKSKL EDMFPAYLQA AFFGKDLLDL SRKALFAVGV GRPGFGLGAS KPRADGGSDR KELMTAMHKG DDGPDVADEE SHGPEGTADL PGLEDGGVKA SPVPSDPEKP GTPGEGVLSS DLDRIPTEEL PKMESKDLQQ LFKDVLGSER EQHLGCGTPG LEGGRTSLQR PFLQGGLALG SLPSSSPMDS YPGLCQSPFL DSRERGGFFS PEPGEPDSPW TGSGGTTPST PTTPTTEGEG DGLSYNQRSL QRWEKDEELG QLSTISPVLY ANINFPNLKQ DYPDWSSRCK QIMKLWRKVP AADKAPYLQK AKDNRAAHRI SKVQKQAESQ ISKQAKMGDI ARKTDRPALH LRIPSQPGAL GSPPPAAAPT IFLGSPTTPA GLSTSADGFL KPPAGTVPGP DSPGELFLKL PPQVPAQVPS QDPFGLAPAY APEPRFSAAP PTYPPYPSPT GAPAQPPMLG TTTRPGTGQP GEFHTTPPGT PRHQPSTPDP FLKPRCPSLD NLAVPESPGV AGGKASEPLL SPPPFGESRK SLEVKKEELG ASSPGYGPPN LGCVDSPSAG PHLGGLELKA PDVFKAPLTP RASQVEPQSP GLGLRAQEPP PAQALAPSPP SHPDVFRSGP YPDPYAQPPL TPRPQPPPPE SCCAPPPRSL PSDPFSRVPA SPQSQSSSQS PLTPRPLSAE AFCPSPVTPR FQSPDPYSRP PSRPQSRDPF APLHKPPRPQ PPEVAFKAGP LAHTPLGAGG FPAALPSGPA GELHAKVPSG QPTNFARSPG TGTFVGTPSP MRFTFPQGVG EPSLKPPVPQ PGLPSPHGIN SHFGPGPTLG KPQSTNYAVA TGNFHPSGSP LGPNSGPTGE GYGLSPLRPA SVLPPPAPDG SLPYLTHGAS QRVGITSPVE KREDPGATMS SSSLATPELS SAQDAGISSL SQTELEKQRQ RQRLRELLIR QQIQRNTLRQ EKETAAAAAG AVGPPGNWGA EPSSPAFEQL SRGQTPFTGS QDRSSIVGLP ASKLGGPTLG PGAFSSDDRL ARPLPPATPS SMDMNSRQLV GGSQAFYQRT PYPGSLPLQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQLWQ QQQQQQQQQQ QQAAAAAAAT SMRLAMSARF PSTPGPELGR QALGSPLAGI PTRLPGPAEP VPGPAGPAQF IELRHNVQKG LGPGVSPFPG QGPPQRPRFY PVSEELHRLA PEGLRGLAVP GLPSQKPSAL PAPELNNSLH QTPHAKGPAL ASGLELVSRP PSNTELSRPP LALEAGKLPC EDPELDDDFD AHKALEDDEE LAHLGLGVDV AKGDDELGTL ENLETNDPHL DDLLNGDEFD LLAYTDPELD TGDKKDIFNE HLRLVESANE KAEREALLRG VEPVSLGPEE RPPPAPDNSE PRLTSVLPEV KPKVEEGGRH PSPCQFTINT PKVEPAPPAT SLSLGLKPGQ TVMGTRDTRG GVGTGSFPSS GHTAEKGPFG ATGGTPAHLL NPSSLSGPAA SSLLEKFELE SGALTLPSGH AAAGDELDKM ESSLVASELP LLIEDLLEHE KKELQKKQQL SAQTVLPAQQ QQQQQQQQQQ QQQQHTLLPT PGPAQALPLP HEPGPPQQLA LGIGSTRQPG LGQSMVPIQP PAHALQQRLA PSVAMVSNQG HMLSGQQAGQ TGLVPQQSSQ PVLAQKPMSA MPASMCMKPQ QLAMQQQQLA NSFFPDTDLD KFAAEDIIDP IAKAKMVALK GIKKVMAQGS IGVAPGMNRQ QVSLLAQRLS GGSGSDLQNH VAPGSGQERN AGDPAQPRPN PPTFAQGVIN EADQRQYEEW LFHTQQLLQM QLKVLEEQIG VHRKSRKALC AKQRTAKKAG REFPEADAEK LKLVTEQQSK IQKQLDQVRK QQKEHTNLMA EYRNKQQQQQ QQQQQQQQQQ HSAVLAVSPS QNPRVLTKLP GQLLPAHGLQ PPQAPPGGQA GGLRLPPGGM VLPGQSGGPF LNTTLAQQQQ QQHSGVAGSL TGPPGSFFPG NLALRSLGPD SRLLQERQLQ LQQQRMQLAQ KLQQQQQQQQ QQQQQQHLLG QVAIQQQQGP GVQNQALGPK PQGLLPPSNH QGLLVQQLSP QQSQGSQGLL GPAQVTVLQQ QQQQQQHSGA LGPQGPHRQV LMTQSRVLSS PQLAQQGHSL MGHRLLTAQQ QQQQQQQQQQ QQQQQQQQQQ QQQGSMTGLS QLQQGMMSHG GQPKMSAQAL GSLQQQQQQL QQQQMLQQQQ LQQQQQQLQQ QQQQQQLQQQ QQQQLQLQQQ QQQQQQHLQH QQQQQQQLQQ QQQLQQQQQQ QLHLQQQLHQ QQQLQLQQQQ MGLLNQNRTL LSPQQQQQQQ QQQQQQQQQQ QQQQQQQQQV TLGPGLPVKP LQHFSSSGAL GPTLLLTGKE QNNAETALPS EVTEGPSTHQ GGPPAVGTAP EPMSVEPGEV KPSISGDSQL LLVQSQAQSQ ATSVQLQPPL RLPGQPQPQV NLLHTAGGGS HGQQLGSGSS SESPAVPHLL AQPSVSLGEQ PGPMAQNLLG SQQPLGLDRP IQNNTGSQPP KSGPAPQSGQ GPPGAGVMPT VGQLRAQLQG VLAKNPQLRH LSPQQQQQLQ ALLMQRQLQQ SQAVRQTPPF QEPGTQPSPL QGLLGCQPQP GGFSVSQTGP LQELGAGSRP QGPPRLPVPQ GALSTGPVLG PAHPTPPPSS PQEPKRPSQL PSPSAQLTPT HPGTPKPQGP ALELPPGRVS PAAAQLADTF FGKGLGPWDP SDNLTEAQKP EQSSLVPGHL DQVNGQVVHE PSQLSIKQEP REEPCALGAQ TVKREANGEP AGAPGTSNHL LLAGSRSEAG HLLLQKLLRA KNVQLGAGRG PEGLRAEING HIDSKLSGLE QKLQGTSSNK EDAATRKPLP AKPKRVQKTS DRLPSSRKKL RKEDGVRANE ALLKQLKQEL SQLPLTEPTI TANFSLFAPF GSGCLVSGQS QLRGAFGSGA LHTGPDYYSQ LLTKNNLSNP PTPPSSLPPT PPPSVQQKMV NGVTPSDELG ERPKDTASAQ DSEGALRDAA EVKSLDLLAA LPTPPHNQTE DVRMESDEDS DSPDSIVPAS SPESILGEEA PRFPQLGSGR WEQDNRALSP VIPIIPRTGI PVFPDTKPYG VLDLEVPGKL PATAWEKGKG SEVSVMLTVS AAAAKNLNGV MVAVAELLSM KIPNSYEVLF PDGPARAGLE PKKGEAEGPG GKEKGLSGKG PDTGPDWLKQ FDAVLPGYTL KSQLDILSLL KQESPAPEPS IQHSYTYNVS NLDVRQLSAP PPEEPSPPPS PLAPSPASPP AEPMVELQAE RPAEPPIPSP LPLASSPESA RPKPRARPPE ESEDSRPPRL KKWKGVRWKR LRLLLTIQKG SGHQEDEREV AEFMEQFGTA LRPSKVPRDN RRCCFCHEEG DGATDGPARL LNLDLDLWVH LNCALWSTEV YETQGGALMN VEVALHRGLL TKCSLCQRTG ATSSCNRMRC PNVYHFACAI RAKCMFFKDK TMLCPVHKIK GPCEQELSSF AVFRRVYIER DEVKQIASII QRGERLHMFR VGGLVFHAIG QLLPHQMADF HSATALYPVG YEATRIYWSL RTNNRRCCYR CSISENNGRP EFVIKVIEQG LEDLVFTDAS PQAVWNRIIE PVAAMRKEAD MLRLFPEYLK GEELFGLTVH AVLRIAESLP GVESCQNYLF RYGRHPLMEL PLMINPTGCA RSEPKILTHY KRPHTLNSTS MSKAYQSTFT GETNTPYSKQ FVHSKSSQYR RLRTEWKNNV YLARSRIQGL GLYAAKDLEK HTMVIEYIGT IIRNEVANRR EKIYEEQNRG IYMFRINNEH VIDATLTGGP ARYINHSCAP NCVAEVVTFD KEDKIIIISS RRIPKGEELT YDYQFDFEDD QHKIPCHCGA WNCRKWMN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.

Subcellular Location

Nucleus.

Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily

Database Links

UNIGENE: Mm.264889

STRING: 10090.ENSMUSP00000135941

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