Recombinant Mouse Integrin alpha-8 (Itga8), partial

1. Role of integrin alpha8 in murine model of lung fibrosis PMID:29813125
2. Itga8-/- renal mesangial cells showed reduced phagocytosis of matrix-coated beads and apoptotic cells compared to WT renal mesangial cells. PMID:29544224
3. alpha8 Integrin is expressed in functional placental compartments among its ligands, OPN and/or FN, across species. Although this may point to a regulatory role in trophoblast function, our data from alpha8 integrin-deficient mice indicated only mild placental pathology. PMID:28136130
4. Study observed that in the Apoe-deficient model of atherosclerosis, the female sex is a risk factor to develop more severe atherosclerotic lesions, although serum fat levels are not higher in females than in males. In contrast, female mice are protected from renal damage induced by the concomitant deficiency of Apoe and Itga8 PMID:28572914
5. Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism. PMID:27092791
6. Itga8 seems to attenuate tubulointerstitial fibrosis in unilateral ureteral obstruction not via regulation of cell turnover, but via regulation of TGF-beta signalling, fibroblast activation and/or immune cell infiltration PMID:26938996
7. Fibrillin-1 and alpha8 integrin interact, and thus, regulate mesangial cell adhesion and migration. PMID:25482639
8. Alpha 8 integrin expression is strongly induced in a mouse model of renal fibrosis. PMID:23144868
9. The findings indicate that QBRICK facilitates the integrin alpha8beta1-dependent interactions of cells with basement membranes by regulating the basement membrane assembly of nephronectin and explain why renal defects occur in Fraser syndrome. PMID:22613833
10. Lack of alpha8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells. PMID:21194485
11. Mice mutant for alpha8-integrin exhibit a specific impairment of long-term potentiation at synapses of Schaffer collateral-CA1 field of the hippocampus. PMID:20132319
12. alpha8-integrin is protective for the structure and function of the glomerulus and maintains podocyte integrity during the development of diabetic nephropathy PMID:20826576
13. Lack of alpha8 causes unilateral or bilateral renal agenesis, significantly reduced renal mass, and higher blood pressure. Many alpha8-deficient mice had malformations of the kidney with collapse or atrophy of tubuli and interstitial cell infiltrates. PMID:12386295
14. Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury. PMID:12787402
15. Integrin alpha8beta1-fibronectin-mediated survival appears to be mediated by the PI3 kinase pathway PMID:15721307
16. Interactions between alpha(8)-integrin and the mesangial matrix may contribute to healing of glomerular injury by influencing cell proliferation and apoptosis PMID:17951999
17. Lack of alpha8 integrin does not reduce fibrotic changes in the hearts of DOCA-salt hypertensive mice. PMID:19008864
18. The induction of -integrin in -smooth muscle actin (-SMA) positive myofibroblasts of the liver and heart suggests that -integrin might modulate the function of activated myofibroblasts, cells contributing to fibrotic remodeling. PMID:19096376
19. we propose that integrin alpha8beta1 plays a critical role in lung morphogenesis by regulating mesenchymal cell adhesion and migration PMID:19769957

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UNIGENE: Mm.329997

KEGG: mmu:241226

STRING: 10090.ENSMUSP00000028106