Recombinant Mouse Tomoregulin-2 (Tmeff2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details

Abbreviation

Tmeff2

Purity

>85% (SDS-PAGE)

Target Names

Tmeff2

Uniprot NO.

Q9QYM9

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form may up-regulate cell proliferation.

Gene References into Functions

Together, these data suggested that Tmeff2 is specifically upregulated in oligodendrocytes, but dispensable for oligodendrocyte differentiation and maturation. PMID:28336932
Results suggest that TMEFF2 is a brain-enriched endogenous modulator of Abeta neurotoxicity and an enhancer of alpha-secretase processing of AbetaPP PMID:26402097
Loss of TMEFF2 is associated with cell migration and invasion leading to prostate cancer. PMID:24632071

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Tomoregulin family

Tissue Specificity

Widely expressed in the brain. In the olfactory bulb expressed in mitral cell, granule, and glomerular layers. In the hippocampus expressed in hippocampal cornu ammonis, pyramidal layer, dentate gyrus, and substantia nigra pars compacta.

Database Links

UNIGENE: Mm.245154

KEGG: mmu:56363

STRING: 10090.ENSMUSP00000080533

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