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Recombinant Mouse Transcription factor ETV6 (Etv6)

Recombinant Mouse Transcription factor ETV6 (Etv6)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Etv6

Uniprot NO.

P97360

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

2-485

Target Protein Sequence

SETPAQSSI KQERISYTPP ESPVASHRSS TPLHVHTVPR ALRMEEDSIH LPTHLRLQPI YWSRDDVAQW LKWAENEFSL RPIESNKFEM NGKALLLLTK EDFRYRSPHS GDVLYELLQH ILKQRKSRML FSPFFPPGDS IHTKPEVLLH QNHDEDNCVQ RTPRTPAESV HHNPPTIELL HRPRSPITTN HRPSPDPEQQ RPQRSPLDNM SRRLSPVEKA QGPRLQQENN HQETYPLSVS PVENNHCLPS SPWQESTRVI QLMPSPIMHP LILNPRHSHS VDFKQSRHSE DGMNREGKPI NLSHREDLAY LNHIMVSMSP PEEHAMPIGR IADCRLLWDY VYQLLSDSRY ENFIRWEDKE SKIFRIVDPN GLARLWGNHK NRTNMTYEKM SRALRHYYKL NIIRKEPGQR LLFRFMKTPD EIMSGRTDRL EHLESQVLDE QTYQEDEPTI ASPVGWPRGN LPTGTAGGVM EAGELGVAVK EETRE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.

Gene References into Functions

Together with similar observations made in human PAX5-ETV6(+) B-ALLs, these data identified PAX5-ETV6 fusion as a potent oncoprotein that drives B-cell leukemia development. PMID:28219927
ETV6 DNA binding inhibition is established by the stability of its inhibitory helix PMID:26920109
ETV6-SAM domain interface mutations block ETV6-NTRK3-induced cellular transformation PMID:23798677
the autoinhibition of ETV6 DNA binding by sequences C-terminal to its ETS domain PMID:22584210
find that both IRS1 and kinase active IGF1R are required for ETV6-NTRK3 transformation, that tyrosine phosphorylated IRS1 is present in high molecular weight complexes with EN and IGF1R, and that EN colocalizes with IGF1R at the plasma membrane PMID:21804605
Cytogenetic study of 33 children with ETV6-RUNX1 positive acute lymphoblastic leukemia predict long term survival. PMID:19998443
TEL binding to IRF-8 for recruitment of HDAC3 is regulated by gamma-interferon PMID:12370291
role in accelerating differentiation of Friend erythroleukemia cells PMID:12527908
the ability of TEL to repress transcription and suppress growth is regulated by sumoylation and nuclear export PMID:12626745
nucleo-cytoplasmic delocalization of the major isoform of TEL-ETV6 is regulated by V-src PMID:12893822
ETV6-NTRK3.IRS-1 complex formation through the NTRK3 C terminus is essential for ETV6-NTRK3 transformation PMID:14668342
establish Tel/Etv6 as a selective and essential regulator of postembryonic hematopoietic stem cells PMID:15371326
leukemogenic effect of meningioma 1-TEL in our knock-in mice is pleiotropic, and the type of secondary mutation determines disease outcome PMID:16105979
Data suggest that TEL exerts a tumor suppressive function through augmenting the p53 pathway. PMID:16828711
alteration of the cellular localization of TEL may be a part of the cellular stress response and re-localization of TEL to the cytoplasm is an important step in the regulation of TEL PMID:18022807
Leukemia-related ETV6 expands erythroid precursors and stimulates hemoglobin synthesis. PMID:19302286