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Recombinant Pig Transcription factor A, mitochondrial (TFAM)

Recombinant Pig Transcription factor A, mitochondrial (TFAM)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

TFAM

Purity

>85% (SDS-PAGE)

Target Names

TFAM

Uniprot NO.

Q5D144

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

43-246

Target Protein Sequence

SSTLSGFPKKPMTSYVRFSKEQLPIFKAQNPDAKNSELIKKIAELWRELPDSEKKIYEDA YRADWQVYKEEVNRIQEQLTPSQMVSLEKEIMQKRLKKKALIKKRELTMLGKPKRPRSAY NIFIAERFQEAKDGPSQVKLKTINENWKNLSSSQKQVYIQLAEDDKVRYYNEMKSWEEQM VEVGRNDLIRRSMKHSAKKDTEEC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.

Gene References into Functions