Recombinant Rabbit Cathepsin K (CTSK)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CTSK

Uniprot NO.

P43236

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Expression Region

115-329

Target Protein Sequence

TPDSID YRKKGYVTPV KNQGQCGSCW AFSSVGALEG QLKKKTGKLL NLSPQNLVDC VSENYGCGGG YMTNAFQYVQ RNRGIDSEDA YPYVGQDESC MYNPTGKAAK CRGYREIPEG NEKALKRAVA RVGPVSVAID ASLTSFQFYS KGVYYDENCS SDNVNHAVLA VGYGIQKGNK HWIIKNSWGE SWGNKGYILM ARNKNNACGI ANLASFPKM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.

Gene References into Functions

The authors showed CTSK upregulation in human lung specimens and elevated serum CTSK levels of patients with tuberculosis, compared with controls. PMID:26416658
Down-regulation of cathepsin K in synovium at the initial stage of osteoarthritis significantly accelerated cartilage degeneration. PMID:19644873

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Subcellular Location

Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side.

Protein Families

Peptidase C1 family

Tissue Specificity

Predominantly expressed in osteclasts (bones).

Database Links

UNIGENE: Ocu.6195

KEGG: ocu:100009334

STRING: 9986.ENSOCUP00000009540

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