Recombinant Rabbit Cytochrome P450 2E1 (CYP2E1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CYP2E1

Uniprot NO.

P08682

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Expression Region

2-493

Target Protein Sequence

AVLGITVAL LGWMVILLFI SVWKQIHSSW NLPPGPFPLP IIGNLLQLDL KDIPKSFGRL AERFGPVFTV YLGSRRVVVL HGYKAVREML LNHKNEFSGR GEIPAFREFK DKGIIFNNGP TWKDTRRFSL TTLRDYGMGK QGNEDRIQKE AHFLLEELRK TQGQPFDPTF VIGCTPFNVI AKILFNDRFD YKDKQALRLM SLFNENFYLL STPWLQVYNN FSNYLQYMPG SHRKVIKNVS EIKEYTLARV KEHHKSLDPS CPRDFIDSLL IEMEKDKHST EPLYTLENIA VTVADMFFAG TETTSTTLRY GLLILLKHPE IEEKLHEEID RVIGPSRMPS VRDRVQMPYM DAVVHEIQRF IDLVPSNLPH EATRDTTFQG YVIPKGTVVI PTLDSLLYDK QEFPDPEKFK PEHFLNEEGK FKYSDYFKPF SAGKRVCVGE GLARMELFLL LSAILQHFNL KPLVDPEDID LRNITVGFGR VPPRYKLCVI PRS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.

Gene References into Functions

The localization of CYP1A2, CYP2B4 and CYP2E1 within the ER was determined by partial membrane solubilization with Brij 98 PMID:25236845
this study indicates that the gender difference in cytochrome P4503A activity may be one of the important factors for the development of steroid-induced osteonecrosis, possibly due to the effects of oestradiol. PMID:24673874

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Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein.

Protein Families

Cytochrome P450 family

Database Links

UNIGENE: Ocu.1853

KEGG: ocu:100342572

STRING: 9986.ENSOCUP00000014766

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