Recombinant Rabbit Interleukin-10 (IL10)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

IL10

Purity

>85% (SDS-PAGE)

Target Names

IL10

Uniprot NO.

Q9TSJ4

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Expression Region

19-178

Target Protein Sequence

SR GQDTPAENSC IHFPGGLPHM LRELRAAFGR VKTFFQSKDQ LNSMLLTESL LEDLKGYLGC QALSEMIQFY LKDVMPQAEN HSPAIREHVN SLGENLKTLR LRLRQCHRFL PCENKSKAVE QVKSAFSKLQ EEGVYKAMSE FDIFINYIET YMTMKIKS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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■ Q&A

Can we use it for culturing and activating B cell from PBMC

Thanks for your inquiry, if you use this protein for culturing and activating B cell from PBMC, please choose the Aseptic Processing and Endotoxin Removal service when placing the order.

Target Background

Function(From Uniprot)

Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.

Subcellular Location

Secreted.

Protein Families

IL-10 family

Database Links

UNIGENE: Ocu.1796

STRING: 9986.ENSOCUP00000019534

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