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Recombinant Rabbit Monocyte differentiation antigen CD14 (CD14)

Recombinant Rabbit Monocyte differentiation antigen CD14 (CD14)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

CD14

Purity

>85% (SDS-PAGE)

Target Names

CD14

Uniprot NO.

Q28680

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Expression Region

18-342

Target Protein Sequence

STD TPEPCELDDD DIRCVCNFSD PQPDWSSALQ CMPAVQVEMW GGGHSLEQFL RQADLYTDQR RYADVVKALR VRRLTVGAVQ VPAPLLLGVL RVLGYSRLKE LALEDIEVTG TAPPPPPLEA TGPALSTLSL RNVSWPKGGA WLSELQQWLK PGLQVLNIAQ AHTLAFSCEQ VRTFSALTTL DLSENPGLGE RGLVAALCPH KFPALQDLAL RNAGMKTLQG VCAALAEAGV QPHHLDLSHN SLRADTQRCI WPSALNSLNL SFTGLQQVPK GLPAKLNVLD LSCNKLNRAP QPGELPKVVN LSLDGNPFLV PGASKLQEDL TN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).

Gene References into Functions

VB-201 may counter inflammation where TLR-2 and/or CD14 complicity is essential, and is therefore beneficial for the treatment of atherosclerosis. PMID:24116867

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus.

Database Links

UNIGENE: Ocu.1842

KEGG: ocu:100008983

STRING: 9986.ENSOCUP00000003648

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