Recombinant Rat Cardiotrophin-1 (Ctf1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Ctf1

Purity

>85% (SDS-PAGE)

Target Names

Ctf1

Uniprot NO.

Q63086

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-203

Target Protein Sequence

MSQREGSLED HQTDSSFSFL PHLEAKIRQT HNLARLLTKY ADQLLEEYVQ QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSALPAL LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP VPEPVATSAL FTSNSAAGVF SAKVLGLHVC GLYGEWVSRT EGDLGQLVPG GVA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Gene References into Functions

Cardiotrophin-1 modulates glucose transport in cardiomyocytes positively or negatively depending on its concentration. PMID:23277190
Cardiomyocytes treated with CT-1 present high spontaneous Ca(2+) release during diastole, a mechanism linked to arrhythmogenicity in the pathologic heart. PMID:22787135
Cardiotrophin 1 is involved in cardiac, vascular, and renal fibrosis and dysfunction. PMID:22733458
Data suggest a key role for CT-1 in cardiac remodeling induced by aldosterone independent of changes in blood pressure levels. PMID:21926338
CT-1 induces VSMCs proliferation, hypertrophy and extracellular matrix production, and is upregulated in hypertension and by aldosterone. CT-1 may represent a new target of vascular wall remodeling in hypertension PMID:20216087
Cardiotrophin-1 promotes the outgrowth of embryonic cranial motor neurons in isolated stage E12 hindbrain explants. PMID:11932952
CT1 has a role in hypertrophy of rat cardiomyocytes as measured by an increase in cell area and enhanced protein: DNA ratio PMID:12027405
Ctf1 has a possible role in post-MI wound healing PMID:14674704
hypertrophic responses to cardiotrophin-1 is mitogen activated protein kinase kinase 5-mitogen-activated protein kinase 7 pathway PMID:15623435
Motoneurons retrogradely transport from the tongue radiolabeled GDNF, BDNF, and cardiotrophin-1; cardiotrophin-1 follows a strict degradation pathway after retrograde transport to the soma. PMID:15659589
CT-1 can affect the expression of GATA4 mRNA and the binding activity of cardiac myocytes PMID:19327894
CT-1 signals through p38, ERK, and Akt in a parallel manner to activate NF-kappa B and that NF-kappa B is required for CT-1 to mediate its full cytoprotective effects in cardiac myocytes. PMID:11448959

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Subcellular Location

Secreted.

Protein Families

IL-6 superfamily

Tissue Specificity

Expressed in the ventricle and atrium of adult rats. Also detected in the lung, kidney, liver, skeletal muscle, stomach and urinary bladder. Not detected in brain, colon, testis, spleen or thymus. Overexpressed in the ventricles in the case of hypertensio

Database Links

UNIGENE: Rn.10253

KEGG: rno:29201

STRING: 10116.ENSRNOP00000025646

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