Recombinant Rat Inhibin beta B chain (Inhbb)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Inhbb

Uniprot NO.

P17491

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

297-411

Target Protein Sequence

GLEC DGRTSLCCRQ QFFIDFRLIG WNDWIIAPTG YYGNYCEGSC PAYLAGVPGS ASSFHTAVVN QYRMRGLNPG PVNSCCIPTK LSSMSMLYFD DEYNIVKRDV PNMIVEECGC A
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene References into Functions

Activin B induced phosphorylation and activation of Smad1/5/8, the BMP-regulated (BR)-Smads. The stimulation of hepcidin transcription by activin B was mediated by ALK2 and ActRIIA, receptors for the TGF-beta family. PMID:27922109
RhoA regulates Activin B-induced stress fiber formation and migration of Bone marrow-derived mesenchymal stem cells. PMID:27693126
Results identified Inhbb as one factor mediating the proliferative effect of Pdx-1 on islet cells. PMID:27620967
Fluorine had no effect on the expression of androgen binding protein and inhibin B mRNA in testis sertoli cells of Sprague Dawley rats. PMID:21033444
p,p'-DDE could inhibit the expression of inhibin B in rat Sertoli cells. PMID:19877505
TNFalpha and IL1alpha supresses inhibin B secretion and expression in rat Sertoli cells PMID:21256182
inhibin is a major regulator of FS, both by transcriptional and nontranscriptional mechanisms. PMID:14561646
inhibin B is the major inhibin in the male rat and that levels relate to Sertoli cell number and activity. PMID:15070852
inhibins A and B differentially antagonize the actions of activins and BMPs to control adrenocortical C(19) steroid production PMID:16601134
Regulation of pituitary Nr5a2, Inhba, and Inhbb transcripts was limited to young animals. PMID:17344471
propose hypothesis that increase in growth rate subsequent to weaning signals circulating inhibin B levels to fall and pituitary adenylate cyclase-activating polypeptide to decrease and these events facilitate the rise in follicle-stimulating hormone b PMID:18160680
The effect of steroidogenic substrates and follicle stimulating hormone on steroid, inhibin A and B, Pro-alphaC and activin A production was evaluated. PMID:19464342
Bacterial lipopolysaccharide increased the production of interleukin 1alpha and activin A, and reduced production of inhibin B, in Sertoli cells from immature male rats. PMID:19524137