Recombinant Rat Lactadherin (Mfge8)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Mfge8

Uniprot NO.

P70490

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

23-427

Target Protein Sequence

ASGDFCDS SLCLNGGTCL MGQDNDIYCL CPEGFTGLVC NETEKGPCSP NPCFHDAKCL VTEDTQRGDI FTEYICQCPV GYSGIHCELG CSTKLGLEGG AIADSQISAS SVYMGFMGLQ RWGPELARLY RTGIVNAWTA SSYDSKPWIQ VDFLRKMRVS GVMTQGASRA GRAEYLKTFK VAYSLDGRRF EFIQDESGTG DKEFMGNQDN NSLKINMFNP TLEAQYIRLY PVSCHRGCTL RFELLGCELH GCSEPLGLKN NTIPDSQITA SSSYKTWNLR AFGWYPHLGR LDNQGKINAW TAQSNSAKEW LQVDLGTQKK VTGIITQGAR DFGHIQYVAS YKVAHSDDGV QWTVYEEQGT SKVFQGNLDN NSHKKNIFEK PFMARYVRVL PLSWHNRITL RLELLGC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Appears to participate in the O-acetylation of GD3 ganglioside sialic acid.

Gene References into Functions

beta-amyloid peptide induced neuronal loss is mediated by the bridging protein lactadherin/milk-fat globule epidermal growth factor-like factor 8 PMID:23647050
Liver and plasma MFG-E8 protein levels were significantly decreased after hepatic ischemia-reperfusion PMID:22487387
Performs important role in cell-cell binding, or in promoting phagocytosis. Specific localization of MFG-E8L(novel long form)in retinal pigment epithelium. PMID:17167398
These results suggested that lactadherin could adjust intestinal DCs activity, induce CD3(+)CD4(+)CD25(+)T cell differentiation, and enhance IL-10 production. PMID:20379374
study shows that OAcGD3S is strongly expressed during liver fibrogenesis and hepatic stellate cells seem to be the major cellular sources of OAcGD3S in the liver PMID:12670504
arterial MFG-E8 significantly increases with aging and is a pivotal relay element within the angiotensin II/MCP-1/VSMC invasion signaling cascade. PMID:19443842