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Recombinant Rat Ras GTPase-activating protein 1 (Rasa1), partial

Recombinant Rat Ras GTPase-activating protein 1 (Rasa1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Rasa1

Uniprot NO.

P50904

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-1038

Target Protein Sequence

MMAAEAGSEE GGPATAGTGG AAATGSSAYP AACRVKLPAA PPMAVAPCPG LADTDLAAAL GGGAASGSGF LGTGPVSGVL GGAALTGGAA AGVAGAAAAG PAGDIALTKG TLSLPAETLG PGGGFPPLPP PPLLPPLGSG LGTVDEGDSL DGPEYEEEEV AIPLTAPPTN QWYHGKLDRT IAEERLRQAG KSGSYLIRES DRRPGSFVLS FLSQTNVVNH FRIIAMCGDY YIGGRRFSSL SDLIGYYSHV SCLLKGEKLL YPVAPPEPVE DRRRVRAILP YTKVPDTDEI SFLKGDMFIV HNELEDGWMW VTNLRTDEQG LIVEDLVEEV GREEDPHEGK IWFHGKISKQ EAYNLLMTVG QVCSFLVRPS DNTPGDYSLY FRTNENIQRF KICPTPNNQF MMGGRYYNSI GDIIDHYRKE QIVEGYYLKE PVPMQDQGQV LNDTVDGKEI YNTIRRKTKD AFYKNIVKKG YLLKKGKGKR WKNLYFILEG SDAQLIYFES EKRATKPKGL IDLSVCSVYV VHDSLFGRPN CFQIVVQHFS EEHYIFYFAG ETPEQAEDWM KGLQAFCSLR KSSPGTSNKR LRQVSSLVLH IEEAHKLPVK HFTNPYCNIY LNSVQVAKTH AREGQNPVWS EEFVFDDLPP DINRFEITLS NKTKKSKDPD ILFMRCQLSR LQKGHATDEW FLLSSHIPLK GIEPGSLRVR ARYSMEKIMP EEEYSEFKEL ILQKELHVVY ALSHVCGQDR TLLASILLKI FLHEKLESLL LCTLNDREIS MEDEATTLFR ATTLASTLME QYMKATATQF VHHALKDSIL KIMESKQSCE LSPSKLEKNE DVNTNLAHLL SILSELVEKI FMASEILPPT LRYIYGCLQK SVQHKWPTNN TMRTRVVSGF VFLRLICPAI LNPRMFNIIS DSPSPIAART LTLVAKSVQN LANLVEFGAK EPYMEGVNPF IKSNKHRMIM FLDELGNVPE LPDTTEHSRT DLSRDLAALH EICVAHSDEL RTLSNERGVQ QHVLKKLLAI TELLQQKQNQ YTKTNDVR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.

Gene References into Functions

miR-335 can be involved in the epididymal development by affecting the expression of RASA1. PMID:20933506
This data suggests that Ras is activated during the initiation of the cellular response to hypoxia-ischemia in both hippocampus and cortex and that this activation is NO-dependent. PMID:14643014
Ras-GAP interacts with Akt and is necessary for its activation, possibly via integrin-linked kinase-mediated phosphorylation of Ser-473 PMID:14707121
an uncleavable N-terminal RasGAP fragment in insulin-secreting cells has a role in increasing resistance toward apoptotic stimuli without affecting glucose-induced insulin secretion PMID:16046410