Recombinant Rat Stathmin (Stmn1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Stmn1

Uniprot NO.

P13668

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

2-149

Target Protein Sequence

ASSDIQVKE LEKRASGQAF ELILSPRSKE SVPEFPLSPP KKKDLSLEEI QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL ERLREKDKHV EEVRKNKESK DPADETEAD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.

Gene References into Functions

Stathmin is enriched in the developing corticospinal tract PMID:26370173
Stathmin therefore mediates hepatocyte resistance to death from oxidative stress by down regulating JNK and maintaining mitochondrial integrity PMID:25285524
JNK- and PKA-mediated STMN Ser-38 and Ser-63 phosphorylation are required to preserve interphase microtubules in response to hyperosmotic stress. PMID:24302736
Stathmin 1 expression was decreased in the experimental animals from 1 to 14 days postseizure and then significantly increased at Days 30 and 60. PMID:22535533
role of stathmin 1 in FcRI-mediated activation of cells of mast cell lineage and might shed light on the diverse response of these cells to IgE or IgE plus antigen. PMID:21625015
Stathmin 1 is involved in the neuroprotective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) in PC12 cells subjected to serum starvation. PMID:20569302
Stathmin expression increases in the uterus when stimulated by embryo implantation and decidualization and may play a role in the early stages of pregnancy. PMID:12639930
Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of this protein is necessary for cJun-mediated anchorage-independent growth. PMID:12743595
role for stathmin in the migration of newborn neurons in the adult brain PMID:14769823
Sustained stathmin levels in differentiating oligodendrocytes, because of overexpression, resulted in enhanced apoptotic susceptibility. PMID:15659612
Given that the microtubule-destabilizing activity of Op18/stathmin is regulated by its phosphorylation, the ASK1-p38 cascade may regulate microtubule dynamics through Op18/stathmin. PMID:16110469