Recombinant Rat Transcription factor PU.1 (Spi1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Spi1

Purity

>85% (SDS-PAGE)

Target Names

Spi1

Uniprot NO.

Q6BDS1

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-271

Target Protein Sequence

MLQACKMEGF PLVAPPSDEL VTYESELYQR QTHDYYSLIG GDGDSHSDHY WDFSTHHVHS EFESFPENHF TELQSVQPPQ LQQLYRHMEL EQMHVLDTPM APPHASLSHQ VSYMPRVCFP YPPLSPAHQQ SSDEEEGERQ SPPLEVSDGE ADGLEPGPGL LHGETGSKKK IRLYQFLLDL LRSGDMKDSI WWVDKDKGTF QFSSKHKEAL AHRWGIQKGN RKKMTYQKMA RALRNYGKTG EVKKVKKKLT YQFSGEVLGR GGLAERRLPP H
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.

Gene References into Functions

PU.1-silenced semi-mature dendritic cells induced partial immune tolerance both in vitro and in vivo, which could be used as a new strategy to promote intestinal transplantation tolerance. PMID:24282365
interaction of mutants with IRF-8 PMID:15688197

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Subcellular Location

Nucleus.

Protein Families

ETS family

Database Links

UNIGENE: Rn.230674

KEGG: rno:366126

STRING: 10116.ENSRNOP00000016306

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