STRSVSSSS YRRMFGGSGT SSRPSSNRSY VTTSTRTYSL GSALRPSTSR SLYSSSPGGA
YVTRSSAVRL RSSMPGVRLL QDSVDFSLAD AINTEFKNTR TNEKVELQEL NDRFANYIDK
VRFLEQQNKI LLAELEQLKG QGKSRLGDLY EEEMRELRRQ VDQLTNDKAR VEVERDNLAE
DIMRLREKLQ EEMLQREEAE STLQSFRQDV DNASLARLDL ERKVESLQEE IAFLKKLHDE
EIQELQAQIQ EQHVQIDVDV SKPDLTAALR DVRQQYESVA AKNLQEAEEW YKSKFADLSE
AANRNNDALR QAKQESNEYR RQVQSLTCEV DALKGTNESL ERQMREMEEN FALEAANYQD
TIGRLQDEIQ NMKEEMARHL REYQDLLNVK MALDIEIATY RKLLEGEESR ISLPLPNFSS
LNLRETNLES LPLVDTHSKR TLLIKTVETR DGQVINETSQ HHDDLE Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal His-tagged/Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
Gene References into Functions
We labeled brain with ZO1, vimentin, pan-cadherin and angiotensin II type 1 receptors markers which showed a morphologically distinct population of cells at the region of the sulcus medianus organum similar to tanycytes present in the median eminence, a known circumventricular organ.PMID:29803674
In transected spinal cord rats, vimentin knockdown in the scar tissues showed a significant improvement on locomotor function in hindlimbs.PMID:24874717
The increased expression of LP-vimentin-IR cells suggests that changes in cell-cell interactions could play a role in ischemia-induced changes in bladder activity.PMID:24728265
Double-immunostaining experiments with antibodies against Stk33 and vimentin showed a striking colocalization of Stk33 and vimentin in the hypothalamus.PMID:24057876
We have identified three protein biomarkers (GSN, MYL2, and VIM) that have potential utility in diagnosing the severity of Chagas diseasePMID:22199233
vimentin is a regulator of NRG1 type III function and peripheral nerve myelinationPMID:22357929
Estradiol treatment leads to an effect on vimentin phosphorylation.PMID:21915674
These data suggest that the inability of YY1 to access the hypermethylated promoter may be one of the mechanisms that mediate vimentin downregulation.PMID:22005459
Data show that vimentin intermediate filaments play a crucial role in mechanical behavior not only at large deformations but also in the nanomechanical response of individual cells.PMID:21426942
Data show that astrocyte structural proteins GFAP and vimentin are induced and by chronic leptin administration, suggesting astrocytes participating in leptin modulated synaptic inputs.PMID:21343257
GR-mediated reduction in vimentin may be involved in the formation of steroid-induced cataractPMID:21245955
Increases in post-traumatic vimentin mRNA in the cortex and in the hippocampus appear together with vimentin immunoreactivity in astrocytes starting at one day after severe trauma.PMID:20479526
Endothelial cell hypoxia causes redistribution of vimentin to a more insoluble and extensive filamentous network that could play a role in endothelial barrier stabilization.PMID:20427712
Vimentin mRNA and protein expression levels increased significantly throughout hepatotumorigenesis. Vimentin is an important node in underlying gene regulatory networks.PMID:20015863
Fetal hepatocytes at the epithelial mesenchymal transition have a higher level of this protein than in fetal hepatocytes.PMID:12496370
induction in glial cells of hippocampus following hyperthermiaPMID:12834255
vimentin may play a key role in the formation of glial scars in the central nervous systemPMID:15684657
demonstrate the alterations of alpha-smooth muscle actin and vimentin localization patterns in the bovine cryptorchid testis as compared to the contralateral scrotal testis during postnatal developmentPMID:16493181
Taken together, these results suggest that vimentin is a novel member of binding partner of PP1c in astrocytes, and vimentin-Ser82 may act as a memory phosphorylation site.PMID:16629905
Vimentin phosphorylation was increased, indicating an accumulation of phosphorylated vimentin associated to the cytoskeleton in hyperthyroidism induced rats.PMID:17306450
Rats fed the homocysteine diet had an increase in Vim.PMID:17485853
vimentin-immunopositive cells localize (in both intact and lesioned brain) in the zone of barrier structures' formation.PMID:18198667
the phosphorylation and the immunoreactivity of cytoskeletal-associated vimentin were increased without altering vimentin expression, suggesting an accumulation of insoluble and phosphorylated vimentin.PMID:18316471
Single impact load also causes changes in the pattern of vimentin immunoreactivity, indicating vimentin dissassembley in cartilage injury modelPMID:18577232
Vimentin was expressed in cells of the outer and inner capsules of all muscle spindles and in newly formed myoblasts and myotubes of regenerating spindles 7 days after graftingPMID:18941770
Vimentin was observed within cells located in the primitive ducts of rat pancreas newborn animals. It was also spotted in alpha cells starting from E12.5 but disappeared soon after birth, likely identifying immature or recently differentiated alpha cells.PMID:19223297