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Recombinant Xenopus laevis Retinoic acid receptor RXR-alpha (rxra)

Recombinant Xenopus laevis Retinoic acid receptor RXR-alpha (rxra)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

rxra

Uniprot NO.

P51128

Species

Xenopus laevis (African clawed frog)

Source

Yeast

Expression Region

1-488

Target Protein Sequence

MSSAAMDTKH FLPLGGRTCA DTLRCTTSWT AGYDFSSQVN SSSLSSSGLR GSMTAPLLHP SLGNSGLNNS LGSPTQLPSP LSSPINGMGP PFSVISPPLG PSMAIPSTPG LGYGTGSPQI HSPMNSVSST EDIKPPPGIN GILKVPMHPS GAMASFTKHI CAICGDRSSG KHYGVYSCEG CKGFFKRTVR KDLTYTCRDS KDCMIDKRQR NRCQYCRYQK CLAMGMKREA VQEERQRGKE RNENEVESSN SANEDMPVEK ILEAEHAVEP KTETYTEANM GLAPNSPSDP VTNICQAADK QLFTLVEWAK RIPHFSELPL DDQVILLRAG WNELLIASFS HRSIAVKDGI LLATGLHVHR NSAHSAGVGA IFDRVLTELV SKMRDMQMDK TELGCLRAIV LFNPDSKGLS NPLEVEALRE KVYASLEAYC KQKYPEQPGR FAKLLLRLPA LRSIGLKCLE HLFFFKLIGD TPIDTFLMEM LEAPHQMT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for rxrs is 9-cis retinoic acid. In the absence of ligand, the rar/rxr heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation.

Subcellular Location

Nucleus.

Protein Families

Nuclear hormone receptor family, NR2 subfamily

Database Links

UNIGENE: Xl.877

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