Recombinant Mouse Coagulation factor XI (F11)

Discontinued

Code: CSB-MP007916MO(A4)-CS-LX

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Size:

20ug100ug1mg

US$100

Quantity:

Express system: Mammalian cell

Tag Info: C-terminal 10xHis-tagged

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Product Details
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Target Background

Product Details

Abbreviation

Recombinant Mouse F11 protein

Purity

Greater than 85% as determined by SDS-PAGE.

Target Names

F11

Uniprot NO.

Q91Y47

Research Area

Others

Source

Mammalian cell

Expression Region

19-624aa

Mol. Weight

69.5 kDa

Protein Length

Full Length of Mature Protein

Tag Info

C-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

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Target Background

Function(From Uniprot)

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

Gene References into Functions

FXI(-/-) mice have a mild hemostatic defect after injury to the saphenous vein but not after transection of the tail or vessels in the abdominal wall. PMID:28677246
FXI protects against sepsis derived from Streptococcus pneumoniae or Klebsiella pneumoniae pneumonia at least in part by enhancing the phagocytic capacity of neutrophils by a mechanism that is independent of activation via FXIIa. PMID:28492700
FXI attenuates part of the allergic response to repeated administration of house dust mite in the airways by a mechanism that is independent of activation via FXII. PMID:27913422
Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease. PMID:26817955
FXI deprivation was shown to slow down atherogenesis in Apoe knockout mice. PMID:26800563
anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin are also required for expression of polyP cofactor activity during FXI activation PMID:24118982
Factor XI antisense oligonucleotides safely prevent thrombus formation on acutely ruptured atherosclerotic plaques in mice. PMID:24947525
Studies indicate that targeting factor XI (FXI) by knocking out the gene prevents arterial and vein thrombosis. PMID:23929304
Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. PMID:21724997
fXI and fXII contribute to thrombus formation even when factor VIIa/tissue factor initiates thrombosis. PMID:20634381
Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development PMID:11841337
FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse. PMID:12008966
FIX and FXI deficiency cause similar effects in the carotid artery injury model PMID:15733058
fXI may have functions in regulation of inflammation or tissue repair distinct from its role in coagulation PMID:15985536
apolipoprotein E receptor 2 (ApoER2, LRP8), a member of the LDL receptor family, is a platelet receptor for FXI. PMID:19661487