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Recombinant Mouse Pro-neuregulin-3, membrane-bound isoform (Nrg3), partial

Recombinant Mouse Pro-neuregulin-3, membrane-bound isoform (Nrg3), partial

Code: CSB-EP016079MO1

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Size:

20ug100ug1mg

US$256

Quantity:

Express system: E.coli

Species: Mus musculus (Mouse)

Tag Info: C-terminal 6xHis-tagged

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Product Details
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Target Background

Product Details

Abbreviation

Recombinant Mouse Nrg3 protein, partial

Purity

≥ 95% as determined by SDS-PAGE.

Target Names

Nrg3

Uniprot NO.

O35181

Research Area

Cancer

Species

Mus musculus (Mouse)

Source

E.coli

Expression Region

1-362aa

Mol. Weight

44.9 kDa

Protein Length

Partial

Tag Info

C-terminal 6xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

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Target Background

Function(From Uniprot)

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors.

Gene References into Functions

Studied the physiologic role of neuregulin3 (NRG3) in regulating glutamatergic transmission in pyramidal neurons. Found NRG3 regulates the SNARE-complex assembly, and NRG3 knockout causes display behavior deficits related to mental illness. PMID:29463705
Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits. PMID:28147272
This study demonistrated that Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action. PMID:24703509
NRG1beta and NRG3 can promote the proliferation of mouse spermatogonia. PMID:21837948
a Neuregulin3 signaling pathway is involved in specification of mammary gland morphogenesis PMID:16140987
used positional cloning to narrow the interval containing scaramanga (ska) to a 75.6-kb interval containing the distal part of the Neuregulin3 (Nrg3) gene PMID:16140987