Abbreviation
Recombinant Human CD37 protein-VLPs (Active)
Purity
Greater than 95% as determined by SEC-HPLC.
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD37 at 10 μg/mL can bind Anti-CD37 recombinant antibody(CSB-RA004928MA1HU). The EC50 is 7.458-9.930 ng/mL.The VLPs (CSB-MP3838) is negative control.
Alternative Names
Leukocyte antigen CD37; Tetraspanin-26 (Tspan-26); CD37; TSPAN26
Species
Homo sapiens (Human)
Expression Region
1-281aa
Target Protein Sequence
MSAQESCLSLIKYFLFVFNLFFFVLGSLIFCFGIWILIDKTSFVSFVGLAFVPLQIWSKVLAISGIFTMGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQVLILRGNGSEAHRVPCSCYNLSATNDSTILDKVILPQLSRLGHLARSRHSADICAVPAESHIYREGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYNRLARYR
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Full Length
Tag Info
C-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Buffer
Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4
Storage
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Lead Time
3-7 business days
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
Shelf Life
The shelf life is related to many factors, storage state, storage temperature and the stability of the product itself. Generally, the shelf life of lyophilized form is 6 months at -20°C/-80°C from the date of receipt.
Datasheet & COA
Please contact us to get it.
Images
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CSB-MP004928HU is detected by Mouse anti-10*His monoclonal antibody.
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Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD37 at 10 μg/ml can bind Anti-CD37 recombinant antibody(CSB-RA004928MA1HU). The EC50 is 7.458-9.930 ng/mL.The VLPs (CSB-MP3838) is negative control.
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The purity of VLPs was greater than 95% as determined by SEC-HPLC
Description
CD37, a tetraspanin enriched on B cells and implicated in lymphoma pathogenesis, forms multimeric complexes that regulate immune cell signaling and migration, making native quaternary structure essential for functional studies. This full-length protein (aa 1–281) is presented as virus-like particles that preserve the native membrane topology and tetramer assembly characteristic of tetraspanins, enabling physiologically relevant binding interactions. Functional ELISA validation demonstrates specific antibody recognition with an EC50 of 7.458–9.930 ng/mL against an anti-CD37 recombinant antibody, confirming proper epitope presentation and supporting use in antibody development campaigns, immune cell trafficking studies, and tumor metastasis models where CD37-mediated cell–cell interactions drive disease progression. Endotoxin levels below 1.0 EU/μg align with standards expected in cell-based migration and invasion assays where inflammatory contamination would confound readouts of CD37's role in B-cell malignancies.
