Recombinant Rat 5-hydroxytryptamine receptor 4 (Htr4)

1. Results indicate that visceral nociceptive transmission through the caudal medulla is negatively modulated by descending serotonin type 4 receptor dependent mechanisms. PMID:28754313
2. Results support a specific role for 5-HT4-receptors in fine-tuning of the dynamic capacity of hippocampal synapses to express synaptic plasticity. PMID:26800645
3. Study suggests a novel role for the 5-HT4 receptor in facilitation of dendrite formation in which intracellular signaling of PKA and the BDNF-TrkB system may be involved. PMID:27894797
4. 5-HT4 receptor regulating insulin secretion and acting as a potential drug target in diabetes treatment PMID:27423314
5. Increased p11 expression by BDNF and imipramine unraveled a 5-HT4R-mediated modulation of cardiac Ca(2+) handling PMID:26427584
6. A novel apical 5-HT4 -mediated bicarbonate secretory pathway and an nitric oxide-dependent inhibitory mechanism are present in the proximal colon PMID:26061462
7. Results indicate that 5-HT4 receptors are not synthesized by cholinergic cells, and thus would be absent from cholinergic terminals. Several non-cholinergic cell populations in the basal forebrain and its target express these receptors. PMID:25183542
8. Anhedonia, not despair or a decline in exploratory interest, may be associated with upregulation of Let-7a and downregulation of Htr4 expression in the hippocampus; hippocampal Htr4 level may be regulated by Let-7a in rats PMID:24582667
9. We conclude that the 5-HT4(a)-receptor may play a more prominent role in the modulation of motor cortico-ponto-cerebellar, cortico-spinal, rubro-spinal, vestibulo-spinal and cortico-nuclear tracts during juvenile development. PMID:24412663
10. Activation of 5-HT4 receptors facilitates expression of long-term depression at hippocampal output synapses in acute rat brain slices. PMID:24505387
11. the 5-HT(4) receptor is a representative of a foetal cardiac gene program, functional in late foetal development and reactivated in heart failure. PMID:23029047
12. Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists. PMID:22226658
13. beta(1)-AR and 5-HT(4) receptor signalling are subject to opposite regulatory control by cGMP generated by soluble guanylyl cyclase in failing hearts. PMID:21901315
14. Up-regulation of 5-HT3 and 5-HT4 receptors expression in the mucosal/submucosal layer is involved to restore the delayed transit after the parasympathetic denervation in rats. PMID:20691988
15. Selective activation of 5-HT(4) receptors improved memory performance in an olfactory associative discrimination task in aged rats PMID:21745655
16. Study revealed that 5-HT4b, 5-HT2A and 5-HT2B coexisted in auricular myocytes of newborn rat, that 5-HT4 activation reduced cAMP concentration, ICaL and intercellular coupling whereas 5-HT2A or 5-HT2B activation conversely enhanced GJIC. PMID:19615378
17. results suggest that 5-HT(4) receptors can modulate GABAergic signalling bidirectionally, depending on the basal PKA activation levels that are determined by neuronal activity PMID:11986365
18. results report that serotonin 4(a) receptors are strongly expressed in respiratory Pre-Boetzinger complex neurons and that their selective activation protects spontaneous respiratory activity PMID:12855812
19. 5-HT4 receptors located within the cholinergic nucleus basalis magnocellularis may play a role in spatial memory PMID:14557615
20. Lysine may be a partial 5-HT4 receptor antagonist and suppresses 5-HT4 receptor-mediated intestinal pathologies and anxiety in rats PMID:14676321
21. Construction of benzimidazoles which attach to Htr4 receptor. PMID:14703122
22. key role for 5-HT4 receptors in the regulation of synaptic plasticity and the determination of the particular properties of stored synaptic information PMID:15537670
23. Positive inotropic response of failing heart to 5-HT(4) stimulation results from increased L-type Ca2+ current/sarcoplamic reticulum Ca(2+) content. PMID:17660386
24. These findings point out 5-HT(4) receptor agonists as a putative class of antidepressants with a rapid onset of action. PMID:17785179
25. Functional 5-HT(2A) and 5-HT(4) receptors are differentially induced in LV hypertrophy and failure. PMID:17936780
26. Serotonin 4a receptors were found predominantly in the neuropilat late embryonic (E18-E20) stages. At birth, expression was predominantly somatic. PMID:18076058
27. complete recovery of associative learning performance in the lesioned rats by 5-HT4 receptor agonists PMID:18485752
28. 5-HT4 receptor-mediated positive inotropic responses in failing rat ventricle were cAMPdependent. PMID:18846035

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UNIGENE: Rn.10094

KEGG: rno:25324

STRING: 10116.ENSRNOP00000025892