Recombinant Rat T-cell-specific surface glycoprotein CD28 (Cd28)

1. this study identified two crucial immune-related molecules-CD28 and NFATc1, as putative targets of miR-145 in human and experimental myasthenia gravis PMID:24043548
2. CD28 superagonist antibody treatment attenuated obliterative bronchiolitis in rat allo-orthotopic tracheal transplantation by preferentially expanding Foxp3-expressing regulatory T cells. PMID:22564625
3. Data demonstrate that the superagonistic monoclonal antibody for CD28, JJ316, preferentially expanded Treg cells. PMID:21487638
4. Data show several homologies across human, rat and mouse in the kinetic of loss of several LAgs such as CD5, CD4 and CD28. PMID:21745657
5. Tongbi Mixture 2 can inhibit T lymphocytes through down-regulating the expressions of CD28 and CD152. PMID:18601859
6. the Th2-response in mercuric chloride-induced autoimmunity requires continuing costimulation via CD28 PMID:12197880
7. Data show that superagonists bind to the laterally exposed C"D loop of the immunoglobulin-like domain of CD28 but conventional, costimulatory monoclonal antibodies recognize an epitope close to the binding site for the natural CD80/CD86 ligands. PMID:12707299
8. translocation to lipid rafts may play an important role in CD28 signaling. PMID:15280538
9. Mechanism for lack of Cbl-b down-regulation may involve the proteasome since blocking proteasomal activity in young T-lymphocytes prevented Cbl-b down regulation while there was no effect in aged T-lymphocytes on Cbl-b expression. PMID:15491677
10. CD28 negative T suppressor cells protect allogenic recipients from acute rejection in rats liver transplantation. PMID:18089392
11. CD28 superagonists elicit 2 qualitatively distinct waves of activation PMID:18357346
12. Targeting the CD28 antigen with a blocking antibody leads to long-term allograft survival by reducing activation of alloantigen-mediated key signaling events in T cells that might be crucial for full T cell activation. PMID:18408588
13. CD28 antibody induces donor-specific tolerance in rat renal allografts PMID:18727698
14. CD2/CD28 costimulation is the strongest T cell stimulus in vivo in rat lamina propria. PMID:19811406

Show More

Hide All

UNIGENE: Rn.10327

KEGG: rno:25660

STRING: 10116.ENSRNOP00000013701