ACVR2B

ACVR2B, also referred to as ActR-IIB or MGC116908, part of the TGF-β superfamily, is a type II transmembrane serine/threonine kinase receptor. This receptor is widely expressed in various tissues, with particularly high levels found on tumor cells. ACVR2B functions by binding to Activin A, which then recruits and phosphorylates type I Activin receptors, such as ALK4 or ALK7, to activate the SMAD2/3 signaling pathway. This pathway regulates cell proliferation, differentiation, and migration. The expression levels of ACVR2B are closely associated with tumor growth, metastasis, and treatment response, making it a significant biomarker for evaluating tumor treatment and prognosis.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ACVR2B at 2 μg/ml can bind Anti-ACVR2A&ACVR2B recombinant antibody (CSB-RA623829MA1HU). The EC₅₀ is 2.983-3.438 ng/mL.

The purity of ACVR2B was greater than 90% as determined by SEC-HPLC

Recombinant Mouse Activin receptor type-2B (Acvr2b), partial (Active)(CSB-MP001261MO1)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Acvr2b at 2 μg/ml can bind Anti-ACVR2A&ACVR2B recombinant antibody (CSB-RA623829MA1HU). The EC₅₀ is 3.560-4.235 ng/mL.

The purity of ACVR2B was greater than 90% as determined by SEC-HPLC

ACVR2B Recombinant Monoclonal Antibody(CSB-RA260702A0HU)

Validated Data

IHC image of CSB-RA260702A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA260702A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

The following ACVR2B reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ACVR2B Antibodies

ACVR2B Proteins

ACVR2B Antibodies

ACVR2B Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA623829ESR1HU	ACVR2B Antibody	Human	ELISA, IHC
CSB-PA292270	ACVR2B Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA206692	ACVR2B Antibody	Human,Mouse,Rat	ELISA,WB
CSB-RA260702A0HU	ACVR2B Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA623829MB1HU	ACVR2B (Bimagrumab Biosimilar) Recombinant Monoclonal Antibody	Human

ACVR2B Proteins

ACVR2B Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP820878CH1 CSB-EP820878CH1 CSB-BP820878CH1 CSB-MP820878CH1 CSB-EP820878CH1-B	Recombinant Chicken Activin receptor type-2B (ACVR2B), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP820878CH CSB-EP820878CH CSB-BP820878CH CSB-MP820878CH CSB-EP820878CH-B	Recombinant Chicken Activin receptor type-2B (ACVR2B), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACVR2B Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF001261RA	Recombinant Rat Activin receptor type-2B (Acvr2b)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP001261RA1 CSB-EP001261RA1 CSB-BP001261RA1 CSB-MP001261RA1 CSB-EP001261RA1-B	Recombinant Rat Activin receptor type-2B (Acvr2b), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACVR2B Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP623829HU	Recombinant Human/Cynomolgus monkey Activin receptor type-2B (ACVR2B), partial	Yeast
CSB-EP623829HU	Recombinant Human/Cynomolgus monkey Activin receptor type-2B (ACVR2B), partial	E.coli
CSB-AP005701HU	Recombinant Human Activin receptor type-2B (ACVR2B), partial (Active)	Mammalian cell
CSB-MP623829HU	Recombinant Human/Cynomolgus monkey Activin receptor type-2B (ACVR2B), partial (Active)	Mammalian cell
CSB-MP623829HUi9	Recombinant Human/Cynomolgus monkey Activin receptor type-2B (ACVR2B), partial (Active)	Mammalian cell
CSB-MP623829HUk7-B	Recombinant Human Activin receptor type-2B (ACVR2B), partial, Biotinylated	Mammalian cell

ACVR2B Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP721106PI CSB-EP721106PI CSB-BP721106PI CSB-MP721106PI CSB-EP721106PI-B	Recombinant Pig Activin receptor type-2B (ACVR2B), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACVR2B Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP853256BO CSB-EP853256BO CSB-BP853256BO CSB-MP853256BO CSB-EP853256BO-B	Recombinant Bovine Activin receptor type-2B (ACVR2B), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ACVR2B Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF001261MO	Recombinant Mouse Activin receptor type-2B (Acvr2b)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP001261MO1 CSB-EP001261MO1 CSB-BP001261MO1 CSB-MP001261MO1 CSB-EP001261MO1-B	Recombinant Mouse Activin receptor type-2B (Acvr2b), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP001261MO1	Recombinant Mouse Activin receptor type-2B (Acvr2b), partial (Active)	Mammalian cell
CSB-YP001261MO1	Recombinant Mouse Activin receptor type-2B (Acvr2b), partial (Active)	Yeast

ACVR2B Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-CF001261XBE	Recombinant Xenopus laevis Activin receptor type-2B (acvr2b)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP001261XBE1 CSB-EP001261XBE1 CSB-BP001261XBE1 CSB-MP001261XBE1 CSB-EP001261XBE1-B	Recombinant Xenopus laevis Activin receptor type-2B (acvr2b), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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