CCND1

CCND1, G1/S-specific cyclin-D1, aliases include BCL1, PRAD1, U21B31, and D11S287E. CCND1 is encoded by the human CCND1 gene, which is located in the q13.3 region of chromosome 11.
CCND1 is a key regulator in the cell cycle, and the proteins that it encodes belong to a highly conserved family of cell cycle proteins that are proteins are significantly periodic in their abundance in the cell cycle. CCND1 forms a complex with and acts as a regulatory subunit of CDK4 or CDK6, and its activity is required for the G1/S transition in the cell cycle.
CCND1 interacts with the tumor suppressor protein Rb and the expression of this gene is positively regulated by Rb. Mutations, amplification, and overexpression of CCND1 alter cell cycle process, which is frequently observed in a variety of human cancers. CCND1 plays a key role in cell proliferation, differentiation and apoptosis, and its aberrant expression is closely related to tumorigenesis and progression, making it an important target for a variety of cancer therapies.