KIF7

Kinesin-like protein KIF7is a protein in humans that is encoded by KIF7 gene. Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation.

The following KIF7 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KIF7 Antibodies

KIF7 Proteins

KIF7 Antibodies

KIF7 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Species Reactivity	Application
CSB-PA704511XA01DIL	kif7 Antibody	Danio rerio (Zebrafish) (Brachydanio rerio)	ELISA, WB (ensure identification of antigen)

KIF7 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-MA000220	KIF7 Monoclonal Antibody	Human,Mouse,Rat	ELISA,IHC

KIF7 Proteins

KIF7 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Code	Product Name	Source
CSB-YP704511DIL CSB-EP704511DIL CSB-BP704511DIL CSB-MP704511DIL CSB-EP704511DIL-B	Recombinant Danio rerio Kinesin-like protein kif7 (kif7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIF7 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP645736HU CSB-EP645736HU CSB-BP645736HU CSB-MP645736HU CSB-EP645736HU-B	Recombinant Human Kinesin-like protein KIF7 (KIF7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIF7 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP012345MO CSB-EP012345MO CSB-BP012345MO CSB-MP012345MO CSB-EP012345MO-B	Recombinant Mouse Kinesin-like protein KIF7 (Kif7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KIF7 Proteins for Dictyostelium discoideum (Slime mold)

Code	Product Name	Source
CSB-YP700886DKK CSB-EP700886DKK CSB-BP700886DKK CSB-MP700886DKK CSB-EP700886DKK-B	Recombinant Dictyostelium discoideum Kinesin-related protein 7 (kif7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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