NPPB

The gene NPPB encodes the B-type natriuretic peptide (BNP), also commonly known as brain natriuretic peptide. This protein is secreted by the ventricles of the heart in response to excessive stretching of cardiomyocytes. BNP binds to the natriuretic peptide receptor A (NPRA), activating the guanylate cyclase pathway, which increases intracellular cGMP levels. This leads to vasodilation and natriuresis, helping to regulate blood pressure and fluid balance.
BNP is closely associated with heart failure. Higher levels in the blood can indicate cardiac stress and are used as a biomarker for diagnosis and prognosis. In drug development, BNP analogs have been explored. For example, nesiritide has been used in the treatment of acute decompensated heart failure to relieve symptoms by enhancing diuresis and reducing cardiac pre - and afterload.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NPPB Recombinant Monoclonal Antibody(CSB-RA016021MA1HU)

Validated Data

Overlay Peak curve showing 786-O cells stained with CSB-RA016021MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG1 (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human brain natriuretic peptide,BNP ELISA Kit(CSB-E07970h)

Validated Data

Code: CSB-E07970h

Size: 96T,5×96T,10×96T

Sensitivity: 23.43 pg/mL

Detection Range: 93.75 pg/mL-6000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following NPPB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

NPPB Antibodies

NPPB Proteins

NPPB ELISA Kits

NPPB Antibodies

NPPB Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA07926A0Rb	NPPB Antibody	Human	ELISA, WB, IHC
CSB-PA07926B0Rb	NPPB Antibody, HRP conjugated	Human	ELISA
CSB-PA07926D0Rb	NPPB Antibody, Biotin conjugated	Human	ELISA
CSB-PA07927D0Rb	NPPB Antibody, Biotin conjugated	Human	ELISA
CSB-PA016021YD01HU	NPPB Antibody, Biotin conjugated	Human	ELISA
CSB-PA016021YC01HU	NPPB Antibody, FITC conjugated	Human
CSB-PA016021YB01HU	NPPB Antibody, HRP conjugated	Human	ELISA
CSB-PA016021YA01HU	NPPB Antibody	Human	ELISA
CSB-PA07927A0Rb	NPPB Antibody	Human	ELISA
CSB-PA07924A0Rb	NPPB Antibody	Human	ELISA, WB
CSB-PA07924D0Rb	NPPB Antibody, Biotin conjugated	Human	ELISA
CSB-MA168601A0m	NPPB Monoclonal Antibody	Human	ELISA,IHC
CSB-PA032496	NPPB Antibody	Human	ELISA,IHC
CSB-PA576064	NPPB Antibody	Human	ELISA,IHC
CSB-PA447744	NPPB Antibody	Human	ELISA,IHC
CSB-RA016021MA1HU	NPPB Recombinant Monoclonal Antibody	Human	ELISA, FC

NPPB Proteins

NPPB Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP016021DO CSB-EP016021DO CSB-BP016021DO CSB-MP016021DO CSB-EP016021DO-B	Recombinant Dog Natriuretic peptides B (NPPB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPPB Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-YP016021SH CSB-EP016021SH CSB-BP016021SH CSB-MP016021SH CSB-EP016021SH-B	Recombinant Sheep Natriuretic peptides B (NPPB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPPB Proteins for Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica)

Code	Product Name	Source
CSB-YP773870OES CSB-EP773870OES CSB-BP773870OES CSB-MP773870OES CSB-EP773870OES-B	Recombinant Oreochromis mossambicus Brain natriuretic peptide (nppb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPPB Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-YP880897CA CSB-EP880897CA CSB-BP880897CA CSB-MP880897CA CSB-EP880897CA-B	Recombinant Cat Natriuretic peptides B (NPPB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPPB Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-EP016021HU(A5)	Recombinant Human natriuretic peptide B (NPPB), partial	E.coli
CSB-EP016021HU-B	Recombinant Human natriuretic peptide B (NPPB), Biotinylated	E.coli

NPPB Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP016021RA CSB-EP016021RA CSB-BP016021RA CSB-MP016021RA CSB-EP016021RA-B	Recombinant Rat Natriuretic peptides B (Nppb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP016021RA1	Recombinant Rat Natriuretic peptides B (Nppb), partial	E.coli
CSB-EP016021RA2	Recombinant Rat Natriuretic peptides B (Nppb), partial	E.coli
CSB-EP016021RA	Recombinant Rat Natriuretic peptides B (Nppb)	E.coli

NPPB Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP016021PI CSB-EP016021PI CSB-BP016021PI CSB-MP016021PI CSB-EP016021PI-B	Recombinant Pig Natriuretic peptides B (NPPB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPPB Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Code	Product Name	Source
CSB-YP800293TKY CSB-EP800293TKY CSB-BP800293TKY CSB-MP800293TKY CSB-EP800293TKY-B	Recombinant Takifugu rubripes Brain natriuretic peptide (nppb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPPB Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP016021BO CSB-EP016021BO CSB-BP016021BO CSB-MP016021BO CSB-EP016021BO-B	Recombinant Bovine Natriuretic peptides B (NPPB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPPB Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP016021MO CSB-EP016021MO CSB-BP016021MO CSB-MP016021MO CSB-EP016021MO-B	Recombinant Mouse Natriuretic peptides B (Nppb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP016021MO	Recombinant Mouse Natriuretic peptides B (Nppb)	E.coli

NPPB ELISA Kit

NPPB ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Sample Types	Sensitivity
CSB-E17436c	Canine brain natriuretic peptide(BNP)ELISA Kit	serum, plasma, tissue homogenates	3.12 pg/mL

NPPB ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E07972r	Rat brain natriuretic peptide,BNP ELISA Kit	serum, plasma, tissue homogenates	31.25 pg/mL

NPPB ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E07970h	Human brain natriuretic peptide,BNP ELISA Kit	serum, urine, tissue homogenates, cell culture supernates	23.43 pg/mL

NPPB ELISA Kit for Sus scrofa (Pig)

Code	Product Name	Sample Types	Sensitivity
CSB-E06807p	Pig brain natriuretic peptide,BNP ELISA Kit	serum, plasma, tissue homogenates	7.8 pg/mL

NPPB ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E07971m	Mouse brain natriuretic peptide,BNP ELISA Kit	serum, plasma, tissue homogenates, cell culture supernates	1.56 pg/mL

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