SUPT20H Antibody

Code: CSB-PA818775ESR1HU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Human, Mouse

Raised in: Rabbit

Application: ELISA, WB, IHC

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Target Background

Product Details

Uniprot NO.

Q8NEM7

Target Names

SUPT20H

Alternative Names

AA667204 antibody; AI450544 antibody; bA421P11.4 antibody; C13 antibody; C13orf19 antibody; D3Ertd300e antibody; FA48A_HUMAN antibody; FAM48A antibody; FP757 antibody; p38-interacting protein antibody; p38IP antibody; Protein FAM48A antibody; RGD1307812 antibody; SPT20 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Transcription factor SPT20 homolog protein (580-779AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: SUPT20H antibody at 0.21μg/ml
Lane 1: Mouse lung tissue
Lane 2: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 86, 81, 89 kDa
Observed band size: 86 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA818775ESR1HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy.

Gene References into Functions

provide the first report that p38-p38IP is required for the Snail-induced E-cadherin down-regulation and cell invasion in HNSCC PMID:27531877
p38IP inhibits ubiquitination-induced GCN5 degradation and therefore promotes alpha-tubulin acetylation, facilitating spindle formation and G2/M progression. PMID:24220028
hSPT20 and other hSAGA subunits, together with RNA polymerase II, are specifically recruited to genes induced by endoplasmic reticulum (ER) stress. PMID:19114550
Manipulation of p38IP and p38alpha alters mAtg9 localization, suggesting p38alpha regulates, through p38IP, the starvation-induced mAtg9 trafficking to forming autophagosomes. PMID:19893488
Novel transcription factors identified in human CD34 antigen-positive hematopoietic stem cells. PMID:12070015
C13orf19 mRNA is down-regulated in matched prostate tissues compared to prostate carcinoma tissues PMID:15978328
C13orf19 is expressed independently of the androgen. No interaction between C13orf19 and p38MAPK was identified. PMID:16685401
mRNA is down-regulated in human prostate cancer, also described as C13 PMID:11340631

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Subcellular Location

Nucleus.

Protein Families

SPT20 family

Tissue Specificity

Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.

Database Links

HGNC: 20596

UNIGENE: Hs.435815

KEGG: hsa:55578

STRING: 9606.ENSP00000218894

OMIM: 613417

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