Recombinant Human Protein FAM48A (FAM48A)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

FAM48A

Purity

>85% (SDS-PAGE)

Target Names

SUPT20H

Uniprot NO.

Q8NEM7

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-779

Target Protein Sequence

MQQALELALD RAEYVIESAR QRPPKRKYLS SGRKSVFQKL YDLYIEECEK EPEVKKLRRN VNLLEKLVMQ ETLSCLVVNL YPGNEGYSLM LRGKNGSDSE TIRLPYEEGE LLEYLDAEEL PPILVDLLEK SQVNIFHCGC VIAEIRDYRQ SSNMKSPGYQ SRHILLRPTM QTLICDVHSI TSDNHKWTQE DKLLLESQLI LATAEPLCLD PSIAVTCTAN RLLYNKQKMN TRPMKRCFKR YSRSSLNRQQ DLSHCPPPPQ LRLLDFLQKR KERKAGQHYD LKISKAGNCV DMWKRSPCNL AIPSEVDVEK YAKVEKSIKS DDSQPTVWPA HDVKDDYVFE CEAGTQYQKT KLTILQSLGD PLYYGKIQPC KADEESDSQM SPSHSSTDDH SNWFIIGSKT DAERVVNQYQ ELVQNEAKCP VKMSHSSSGS ASLSQVSPGK ETDQTETVSV QSSVLGKGVK HRPPPIKLPS SSGNSSSGNY FTPQQTSSFL KSPTPPPSSK PSSIPRKSSV DLNQVSMLSP AALSPASSSQ RTTATQVMAN SAGLNFINVV GSVCGAQALM SGSNPMLGCN TGAITPAGIN LSGLLPSGGL LPNALPSAMQ AASQAGVPFG LKNTSSLRPL NLLQLPGGSL IFNTLQQQQQ QLSQFTPQQP QQPTTCSPQQ PGEQGSEQGS TSQEQALSAQ QAAVINLTGV GSFMQSQAAV LSQLGSAENR PEQSLPQQRF QLSSAFQQQQ QQIQQLRFLQ HQMAMAAAAA QTAQLHHHRH TGSQSKSKMK RGTPTTPKF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy.

Gene References into Functions

provide the first report that p38-p38IP is required for the Snail-induced E-cadherin down-regulation and cell invasion in HNSCC PMID:27531877
p38IP inhibits ubiquitination-induced GCN5 degradation and therefore promotes alpha-tubulin acetylation, facilitating spindle formation and G2/M progression. PMID:24220028
hSPT20 and other hSAGA subunits, together with RNA polymerase II, are specifically recruited to genes induced by endoplasmic reticulum (ER) stress. PMID:19114550
Manipulation of p38IP and p38alpha alters mAtg9 localization, suggesting p38alpha regulates, through p38IP, the starvation-induced mAtg9 trafficking to forming autophagosomes. PMID:19893488
Novel transcription factors identified in human CD34 antigen-positive hematopoietic stem cells. PMID:12070015
C13orf19 mRNA is down-regulated in matched prostate tissues compared to prostate carcinoma tissues PMID:15978328
C13orf19 is expressed independently of the androgen. No interaction between C13orf19 and p38MAPK was identified. PMID:16685401
mRNA is down-regulated in human prostate cancer, also described as C13 PMID:11340631

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Subcellular Location

Nucleus.

Protein Families

SPT20 family

Tissue Specificity

Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.

Database Links

HGNC: 20596

UNIGENE: Hs.435815

KEGG: hsa:55578

STRING: 9606.ENSP00000218894

OMIM: 613417

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